Prognostic Prediction of BRCA Mutations by [.sup.18]F-FDG PET/CT [SUV.sub.max] in Breast Cancer/Meme Kanserlerinde BRCA Mutasyonlarinin [.sup.18]F-FDG PET/BT [SUV.sub.mean] Degeri ile Prognostik Tahmini

• Published in: Molecular imaging and radionuclide therapy 2021-10, Vol.30 (3), p.158
• Main Authors: Özdemir, Semra, Silan, Fatma, Yilmaz Akgün, Mehmet, Araci, Nilgun, Çirpan, Ismail, Koç Öztürk, Fulya, Özdemir, Öztürk
• Format: Article
• Language: English
• Subjects: BRCA mutations; Breast cancer; Cancer; CT imaging; Genetic aspects; Oncology, Experimental; PET imaging; Prognosis
• ISSN: 2146-1414
• DOI: 10.4274/mirt.galenos.2021.82584

Objectives: This study aimed to investigate the prognostic prediction of germline BRCA1 and BRCA2 mutations by comparing the maximum standardized uptake value (SUV ) obtained from [.sup.18]fluoride-fluorodeoxyglucose positron emission tomography/computed tomography ( (18) F-FDG PET/CT), which is considered a prognostic factor in breast cancer (BC). Methods: Retrospective interdisciplinary laboratory results of 92 patients with BC who had germline BRCA1 or BRCA2 mutation profiles and underwent [.sup.18]F-FDG PET/CT were compared. Genotyping was made by next-generation sequencing, and PET/CT scans were re-evaluated. The histopathological data, genetic results, and clinical demographics of all patients were recorded. Patients were divided into two groups in accordance with the presence of germline BRCA1 and/or BRCA2 mutations. Between-group statistical comparison was performed. Results: In PET/CT performed for primary staging, patients with BRCA-positive BC had significantly higher SUV (p=0.039), larger tumor size (p=0.025), and presence of axillary nodal metastases (p=0.023) than patients with BRCA-negative BC. Although the Ki-67 index was higher in the BRCA-positive group than BRCA-negative group, this difference was not significant (p=0.157). Moreover, in the BRCA-positive and negative groups, SUV, Ki-67 index, and tumor size, grade, and stage were significantly correlated with each other. Conclusion: The results of this study showed a strong association between BRCA mutations and SUV, which indicates the poor prognosis of BC. Keywords: BRCA1-2 mutation, SUV, [.sup.18]F-FDG PET/CT, breast cancer Amaç: Bu çalismanin amaci, meme kanserlerinde (MK) germline BRCA1-BRCA2 mutasyonlarinin tahmini prognostik degerini, [.sup.18]F-florodeoksiglikoz pozitron emisyon tomografi/bilgisayarli tomografi ( (18) F-FDG PET/BT) tetkikinden elde edilen ve prognostik bir faktör oldugu kabul edilen maksimum standardize tutulum degeri (SUV k ) ile karsilastirarak arastirmaktir. Yöntem: Germline BRCA1 veya BRCA2 mutasyon profilleri olan ve [.sup.18]F-FDG PET/BT taramasi yapilan MK'li 92 hastanin retrospektif olarak laboratuvar sonuçlari karsilastirildi. Genotipleme yeni nesil siralama teknigi ile yapildi ve PET/BT taramalari yeniden degerlendirilerek tüm hastalarin histopatolojik, genetik sonuçlari ve klinik demografik özellikleri not edildi. Hastalar germline BRCA1 ve/veya BRCA2 mutasyonlarinin varligina göre iki gruba ayrildi ve gruplar arasinda istatistiksel karsilastirma yapil