Antioxidant Properties of a Nanostructured Clathrate Complex Selenopyran with [beta]-Cyclodextrin in Model Systems of Oxidative Stress

We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with [beta]-cyclodextrin on the generation of O[H.sup.*] radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37[degrees]C for 1 h. The complex inh...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-08, Vol.171 (2), p.247
Main Authors: Dzikovskaya, L.A, Degtyareva, E.S, Shegai, P.V, Ivanov, S.A, Kaprin, A.D
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Clathrate compounds
Cyclodextrins
Ethylenediaminetetraacetic acid
Liver
Oxidative stress
Selenium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the effect of nanostructured clathrate complex 9-phenyl-symm-octahydoselenoxanthene (selenopyran) with [beta]-cyclodextrin on the generation of O[H.sup.*] radicals in the Fenton system and parameters of oxidative stress in rat liver cells incubated at 37[degrees]C for 1 h. The complex inhibits the development of free-radical oxidative processes induced by ROS and the most toxic O[H.sup.*] radicals, reduces the increased level of ROS induced by prooxidants, and exhibits antioxidant activity. Key Words: selenium; Fenton system; malondialdehyde (MDA); 2',7'-dichlorofluorescein; liver cells
ISSN:0007-4888
DOI:10.1007/s10517-021-05204-5