Effect of [alpha]2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of [I.sub.f] Blockade

The study examined the effect of [[alpha].sub.2]-adrenoreceptor ([[alpha].sub.2]-AR) activation against the background of preliminary blockage of [I.sub.f] on the performance of Langerndorff-isolated rat heart. Stimulation of [[alpha].sub.2]-AR in isolated rat hearts against the background of ZD7288...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-02, Vol.169 (5), p.635
Main Authors: Ziyatdinova, N.I, Kuptsova, A.M, Sungatullina, M.I, Zefirov, T.L
Format: Article
Language:English
Subjects:
Dexmedetomidine
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Summary:The study examined the effect of [[alpha].sub.2]-adrenoreceptor ([[alpha].sub.2]-AR) activation against the background of preliminary blockage of [I.sub.f] on the performance of Langerndorff-isolated rat heart. Stimulation of [[alpha].sub.2]-AR in isolated rat hearts against the background of ZD7288 in concentrations of [10.sup.-9] M and 3x[10.sup.-5] M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p
ISSN:0007-4888
DOI:10.1007/s10517-020-04943-1