2-adrenergic receptor expression and the effects of norepinephrine and propranolol on various head and neck cancer subtypes

The present study aimed to investigate expression of [beta]2-adrenergic receptor (AR), the effect of the stress-related neurotransmitter norepinephrine (NE) on cell viability, proliferation and the therapeutic effect of propranolol, which is a typical [beta]-blocker in various type of head and neck...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2021-11, Vol.22 (5), p.1
Main Authors: Kwon, Soon Young, Chun, Kyung Ju, Jung, Narae, Shin, Hyun-Ah, Jang, Jeon Yeob, Choi, Hyo Geun, Oh, Kyoung-Ho, Kim, Min-Su
Format: Article
Language:English
Subjects:
Analysis
Aprotinin
DNA polymerases
Head and neck cancer
Health aspects
Immunohistochemistry
Propranolol hydrochloride
Scientific equipment and supplies industry
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study aimed to investigate expression of [beta]2-adrenergic receptor (AR), the effect of the stress-related neurotransmitter norepinephrine (NE) on cell viability, proliferation and the therapeutic effect of propranolol, which is a typical [beta]-blocker in various type of head and neck cancers for the first time. The [beta]2-AR expression was investigated using immunohistochemistry and an immunoreactive scoring (IRS) system in 57 different head and neck cancer specimens, and reverse transcriptase-polymerase chain reaction and western blotting in four head and neck cancer cell lines (HNCCLs). Cell viability and proliferation assays were performed using 0, 1, 5 and 10 [micro]M of NE and 1 [micro]M of propranolol in four HNCCLs. The expression of [beta]2-AR was positive in the majority of head and neck cancer tissues (55/57, 96.5%); however, it was signifcantly higher in oral cavity cancer than in pharyngeal cancer (median IRS: 9 vs. 3; P
ISSN:1792-1074
DOI:10.3892/ol.2021.13065