Role of 11[beta]HSD1, rs12086634, and rs846910 single-nucleotide polymorphisms in metabolic-related skin diseases: a clinical, biochemical, and genetic study

• Published in: Clinical, cosmetic and investigational dermatology cosmetic and investigational dermatology, 2019-01, Vol.12, p.91
• Main Authors: Farag, Azza Gaber Antar, Badr, Eman A.E, Eltorgoman, Abdel Monem A, Assar, Mohamed F.A, Elshafey, Eman N, Tayel, Nermin Reda, Aboutaleb, Hossam E.A
• Format: Article
• Language: English
• Subjects: Acne; Cortisone; Ethylenediaminetetraacetic acid; Genetic aspects; Genetic research; Low density lipoproteins; Medical research; Medicine, Experimental; Single nucleotide polymorphisms; Skin; Type 2 diabetes
• ISSN: 1178-7015; 1178-7015
• DOI: 10.2147/CCID.S193156

Background: 11[beta]HSD1 generates cortisol from cortisone. 11[beta]HSD1 single-nucleotide polymorphism (SNP) was associated with metabolic syndrome (MeTS). Although the relation of acne vulgaris (AV) and skin tags (STs) with MeTS has been reported, the relationship between 11[beta]HSD1 SNP and cortisol activity in those patients has not studied till now. Aims: To investigate, two 11[beta]-HSD1 SNPs (rs846910 and rs12086634), serum lipid profile and cortisol levels in patients with AV and STs in an Egyptian population. Patients and methods: This case-control study was performed on 50 patients having STs and 50 complaining of AV and 50 sex- and age-matched controls. We searched for serum lipid profile, cortisol levels, and 11[beta]-HSD1 rs846910 and rs12086634 SNPs using real time-PCR. Results: Compared to controls, 11[beta]-HSD1 rs846910 GA genotype carriers had significantly higher risks for developing AV and STs by 3.4- and 4.9-fold, respectively, and its A allele increases these risks by 3.1 and 4.4 times, respectively. Also, 11[beta]-HSD1 rs12086634 TG genotype increases the risk of AV by 3.2-fold, as well as STs by 3.5-fold, and its G allele increases the risk of AV by 3.2-fold and STs by 7-fold. In AV and ST patients, rs846910 GA genotype demonstrated significant associations with elevated body mass index (BMI), and cholesterol, low density lipoprotein (LDL), cortisol, and decreased high density lipoprotein serum levels, respectively. However, rs12086634 GG genotype was significantly associated with increased BMI, cholesterol, and LDL serum levels in patients with AV and STs, in addition to the number of STs and serum cortisol levels in ST patients. Conclusion: 11[beta]-HSD1 rs846910 and rs12086634 gene polymorphisms may contribute to AV and STs pathogenesis, that may be mediated through enhancing the enzymatic activity (increasing cortisol levels). AV and STs are associated with obesity and atherogenic lipid profile. Diagnosis of AV and STs may play a role in early detection of the MeTS. Keywords: skin tags, acne vulgaris, metabolic syndrome, 11betahydroxysteroid dehydrogenase, single-nucleotide polymorphism