Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model

Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified B...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-11, Vol.34 (6), p.2159
Main Authors: Kim, Hong-Geol, Ko, Seok-Jae, Hong, Burmgi, Kim, Jinsung, Lee, Beomjoon, Joo, Hyejin, Yoo, Hye Hyun, Kim, In Sook, Jung, Hwan-Su, Chang, Won Kyu, Kim, Hyun-Chul, Bu, Youngmin, Park, Jae-Woo
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Care and treatment
Colitis
Colitis - chemically induced
Colitis - metabolism
Colitis - pathology
Colitis - prevention & control
Colon - drug effects
Colon - metabolism
Colon - pathology
Cytokines - metabolism
Dextran Sulfate
Disease Models, Animal
Drugs, Chinese Herbal - pharmacology
Gastrointestinal agents
Inflammation Mediators - metabolism
Male
Medicine, Botanic
Medicine, Herbal
Mice
Mice, Inbred BALB C
Pharmacology, Experimental
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Summary:Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified BGT, was developed by mixing the extracts of Lonicera japonica Thunb., Alisma orientalis and Atractylodes macrocephala based on a literature review and screening of 16 kinds of component herbs of BGT. A colitis mouse (Male, BALB/c) model was induced using dextran sulfate sodium (5%). The effects of BGT and mBGT on body weight, histological damage, clinical score, macroscopic score and colon length were compared. The mechanisms of action were analyzed based on cytokine production in colon tissue. mBGT at 300mg/kg showed similar effectiveness to that of BGT on colon shortening (P
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.6.REG.2159-2165.1