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Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model
Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified B...
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| Published in: | Pakistan journal of pharmaceutical sciences 2021-11, Vol.34 (6), p.2159 |
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| Main Authors: | , , , , , , , , , , , , |
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| container_issue | 6 |
| container_start_page | 2159 |
| container_title | Pakistan journal of pharmaceutical sciences |
| container_volume | 34 |
| creator | Kim, Hong-Geol Ko, Seok-Jae Hong, Burmgi Kim, Jinsung Lee, Beomjoon Joo, Hyejin Yoo, Hye Hyun Kim, In Sook Jung, Hwan-Su Chang, Won Kyu Kim, Hyun-Chul Bu, Youngmin Park, Jae-Woo |
| description | Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified BGT, was developed by mixing the extracts of Lonicera japonica Thunb., Alisma orientalis and Atractylodes macrocephala based on a literature review and screening of 16 kinds of component herbs of BGT. A colitis mouse (Male, BALB/c) model was induced using dextran sulfate sodium (5%). The effects of BGT and mBGT on body weight, histological damage, clinical score, macroscopic score and colon length were compared. The mechanisms of action were analyzed based on cytokine production in colon tissue. mBGT at 300mg/kg showed similar effectiveness to that of BGT on colon shortening (P |
| doi_str_mv | 10.36721/PJPS.2021.34.6.REG.2159-2165.1 |
| format | article |
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The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified BGT, was developed by mixing the extracts of Lonicera japonica Thunb., Alisma orientalis and Atractylodes macrocephala based on a literature review and screening of 16 kinds of component herbs of BGT. A colitis mouse (Male, BALB/c) model was induced using dextran sulfate sodium (5%). The effects of BGT and mBGT on body weight, histological damage, clinical score, macroscopic score and colon length were compared. The mechanisms of action were analyzed based on cytokine production in colon tissue. mBGT at 300mg/kg showed similar effectiveness to that of BGT on colon shortening (P<0.01), clinical score (P<0.05), macroscopic score (P<0.01) and histological damage (P<0.01). In addition, mBGT decreased cytokines, including Interleukin 1 beta, tumor necrosis factor alpha and Interleukin 17, in a dose-dependent manner. In conclusion, mBGT could be a substitute prescription for BGT in clinics and a candidate for the development of a new BGT-based therapeutic agent against colitis.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2021.34.6.REG.2159-2165.1</identifier><identifier>PMID: 35034876</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Care and treatment ; Colitis ; Colitis - chemically induced ; Colitis - metabolism ; Colitis - pathology ; Colitis - prevention & control ; Colon - drug effects ; Colon - metabolism ; Colon - pathology ; Cytokines - metabolism ; Dextran Sulfate ; Disease Models, Animal ; Drugs, Chinese Herbal - pharmacology ; Gastrointestinal agents ; Inflammation Mediators - metabolism ; Male ; Medicine, Botanic ; Medicine, Herbal ; Mice ; Mice, Inbred BALB C ; Pharmacology, Experimental</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2021-11, Vol.34 (6), p.2159</ispartof><rights>COPYRIGHT 2021 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35034876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hong-Geol</creatorcontrib><creatorcontrib>Ko, Seok-Jae</creatorcontrib><creatorcontrib>Hong, Burmgi</creatorcontrib><creatorcontrib>Kim, Jinsung</creatorcontrib><creatorcontrib>Lee, Beomjoon</creatorcontrib><creatorcontrib>Joo, Hyejin</creatorcontrib><creatorcontrib>Yoo, Hye Hyun</creatorcontrib><creatorcontrib>Kim, In Sook</creatorcontrib><creatorcontrib>Jung, Hwan-Su</creatorcontrib><creatorcontrib>Chang, Won Kyu</creatorcontrib><creatorcontrib>Kim, Hyun-Chul</creatorcontrib><creatorcontrib>Bu, Youngmin</creatorcontrib><creatorcontrib>Park, Jae-Woo</creatorcontrib><title>Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified BGT, was developed by mixing the extracts of Lonicera japonica Thunb., Alisma orientalis and Atractylodes macrocephala based on a literature review and screening of 16 kinds of component herbs of BGT. A colitis mouse (Male, BALB/c) model was induced using dextran sulfate sodium (5%). The effects of BGT and mBGT on body weight, histological damage, clinical score, macroscopic score and colon length were compared. The mechanisms of action were analyzed based on cytokine production in colon tissue. mBGT at 300mg/kg showed similar effectiveness to that of BGT on colon shortening (P<0.01), clinical score (P<0.05), macroscopic score (P<0.01) and histological damage (P<0.01). In addition, mBGT decreased cytokines, including Interleukin 1 beta, tumor necrosis factor alpha and Interleukin 17, in a dose-dependent manner. In conclusion, mBGT could be a substitute prescription for BGT in clinics and a candidate for the development of a new BGT-based therapeutic agent against colitis.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Care and treatment</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - metabolism</subject><subject>Colitis - pathology</subject><subject>Colitis - prevention & control</subject><subject>Colon - drug effects</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Cytokines - metabolism</subject><subject>Dextran Sulfate</subject><subject>Disease Models, Animal</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Gastrointestinal agents</subject><subject>Inflammation Mediators - metabolism</subject><subject>Male</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Pharmacology, Experimental</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNptkE9LAzEQxXNQbK1-BQl48LTrTrKbbI611KoULNqDtyWbTGrq_inNLui3d0v1IMgcZhje-_F4hNxAEnMhGdyunlavMUsYxDyNRfwyX8QMMhUxEFkMJ2QMCUAkEngbkfMQtkkiUqXUGRnxLOFpLsWYfEybzkemrXznDUXn0HSBto5270jr1nrn0dK7dqubzaZvSh91w0Xbhlr87Pa6oaGvnO6QhkHc15FvbG8GS932AekRHA4krC7IqdNVwMufPSHr-_l69hAtnxePs-ky2jCZd5FgBsqUC5YIlqGUkuUObKZ0qhVwa6EEqa0ChWA552lq8tKyQyMoMZd8Qq6P2I2usPCNa4ecpvbBFFORKzUAs4Mq_kc1jMXam7ZB54f_H8PV0bDryxptsdv7Wu-_it8u-TdJgndX</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Kim, Hong-Geol</creator><creator>Ko, Seok-Jae</creator><creator>Hong, Burmgi</creator><creator>Kim, Jinsung</creator><creator>Lee, Beomjoon</creator><creator>Joo, Hyejin</creator><creator>Yoo, Hye Hyun</creator><creator>Kim, In Sook</creator><creator>Jung, Hwan-Su</creator><creator>Chang, Won Kyu</creator><creator>Kim, Hyun-Chul</creator><creator>Bu, Youngmin</creator><creator>Park, Jae-Woo</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202111</creationdate><title>Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model</title><author>Kim, Hong-Geol ; Ko, Seok-Jae ; Hong, Burmgi ; Kim, Jinsung ; Lee, Beomjoon ; Joo, Hyejin ; Yoo, Hye Hyun ; Kim, In Sook ; Jung, Hwan-Su ; Chang, Won Kyu ; Kim, Hyun-Chul ; Bu, Youngmin ; Park, Jae-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-62c1b43620625e77728f1d59a4a913dd1b17ad919e1d33344c8bd26721e7e873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Care and treatment</topic><topic>Colitis</topic><topic>Colitis - chemically induced</topic><topic>Colitis - metabolism</topic><topic>Colitis - pathology</topic><topic>Colitis - prevention & control</topic><topic>Colon - drug effects</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Cytokines - metabolism</topic><topic>Dextran Sulfate</topic><topic>Disease Models, Animal</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Gastrointestinal agents</topic><topic>Inflammation Mediators - metabolism</topic><topic>Male</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Pharmacology, Experimental</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hong-Geol</creatorcontrib><creatorcontrib>Ko, Seok-Jae</creatorcontrib><creatorcontrib>Hong, Burmgi</creatorcontrib><creatorcontrib>Kim, Jinsung</creatorcontrib><creatorcontrib>Lee, Beomjoon</creatorcontrib><creatorcontrib>Joo, Hyejin</creatorcontrib><creatorcontrib>Yoo, Hye Hyun</creatorcontrib><creatorcontrib>Kim, In Sook</creatorcontrib><creatorcontrib>Jung, Hwan-Su</creatorcontrib><creatorcontrib>Chang, Won Kyu</creatorcontrib><creatorcontrib>Kim, Hyun-Chul</creatorcontrib><creatorcontrib>Bu, Youngmin</creatorcontrib><creatorcontrib>Park, Jae-Woo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hong-Geol</au><au>Ko, Seok-Jae</au><au>Hong, Burmgi</au><au>Kim, Jinsung</au><au>Lee, Beomjoon</au><au>Joo, Hyejin</au><au>Yoo, Hye Hyun</au><au>Kim, In Sook</au><au>Jung, Hwan-Su</au><au>Chang, Won Kyu</au><au>Kim, Hyun-Chul</au><au>Bu, Youngmin</au><au>Park, Jae-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2021-11</date><risdate>2021</risdate><volume>34</volume><issue>6</issue><spage>2159</spage><pages>2159-</pages><issn>1011-601X</issn><abstract>Bojanggunbi-tang (BGT) is a well-known and widely used herbal prescription in Korea for colon diseases, with well-documented pharmacological effects on the digestive system. The current study aimed to develop a new simple and effective prescription using the original prescription. mBGT, a modified BGT, was developed by mixing the extracts of Lonicera japonica Thunb., Alisma orientalis and Atractylodes macrocephala based on a literature review and screening of 16 kinds of component herbs of BGT. A colitis mouse (Male, BALB/c) model was induced using dextran sulfate sodium (5%). The effects of BGT and mBGT on body weight, histological damage, clinical score, macroscopic score and colon length were compared. The mechanisms of action were analyzed based on cytokine production in colon tissue. mBGT at 300mg/kg showed similar effectiveness to that of BGT on colon shortening (P<0.01), clinical score (P<0.05), macroscopic score (P<0.01) and histological damage (P<0.01). In addition, mBGT decreased cytokines, including Interleukin 1 beta, tumor necrosis factor alpha and Interleukin 17, in a dose-dependent manner. In conclusion, mBGT could be a substitute prescription for BGT in clinics and a candidate for the development of a new BGT-based therapeutic agent against colitis.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>35034876</pmid><doi>10.36721/PJPS.2021.34.6.REG.2159-2165.1</doi></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Care and treatment Colitis Colitis - chemically induced Colitis - metabolism Colitis - pathology Colitis - prevention & control Colon - drug effects Colon - metabolism Colon - pathology Cytokines - metabolism Dextran Sulfate Disease Models, Animal Drugs, Chinese Herbal - pharmacology Gastrointestinal agents Inflammation Mediators - metabolism Male Medicine, Botanic Medicine, Herbal Mice Mice, Inbred BALB C Pharmacology, Experimental |
| title | Anti-colitic effects of the modified Bojanggunbi-tang on dextran sulfate sodium-induced mouse colitis model |
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