Immunological Evaluation of Children with Crimean-Congo Hemorrhagic Fever in Addition to Routine Clinical and Laboratory Tests Who Were Admitted to Sivas, Cumhuriyet University/Sivas, Cumhuriyet Universitesi'ne Basvuran Kirim-Kongo Kanamali Ates'li Cocuklarin Klinik ve Rutin Laboratuvar Testleri Yaninda Immunolojik Acidan Degerlendirilmesi

• Published in: Güncel pediatri 2015-04, Vol.13 (1), p.13
• Main Authors: Demir, Mevlut, Duksal, Fatma, Dogan, Melih Timucin, Aygunes, Utku, Kaya, Ali, Guven, Ahmet Sami, Cevit, Omer
• Format: Article
• Language: Turkish
• Subjects: Care and treatment; Children; Crimean hemorrhagic fever; Diagnosis; Diseases; Health aspects; Immunoglobulins; Measurement
• ISSN: 1304-9054
• DOI: 10.4274/jcp.51523

Introduction: In our study, it was aimed to evaluate clinical and routine laboratory findings and serum immunoglobulin and complement levels of pediatric patients with the diagnosis of Crimean-Congo Hemorrhagic Fever (CCHF). Materials and Methods: Medical records of 72 patients that diagnosed with CCHF proven by ELISA or polymerase chain reaction (PCR) in Sivas, Cumhuriyet University between 2011 and 2012 were reviewed retrospectively. The information about the epidemiological, clinical features and laboratory findings were recorded. Results: Seventy-two patients who participated in the study, (mean age11.95 [+ or -] 3.95 years) came from Tokat, Sivas, Yozgat, Giresun and Erzincan. During the admission, patients mainly had fever (94.4%), vomiting (54.2%), fatigue (52.8%), anorexia (50%), headache (47.2%), upper respiratory tract infection findings (41.7%); rarely, petechiae-purpura, ecchymosis, epistaxis, diarrhea, melena, maculopapular rash, hematemesis, hematuria, hepatomegaly, splenomegaly, lymphadenopathy were seen. At admission, laboratory findings of the patients were as follows; thrombocytopenia, 80.6%; leucopenia,70.8%; neutropenia, 50%; high aspartate transaminase, 73.6%; high alanine transaminase, 26.4%; high lactate dehydrogenase 71.6%; high creatine kinase, 68.1%; prolonged protrombine time, 54.2%; prolonged partial thromboplastin time, 52.8%. In addition low IgG, low IgA, low C3, low C4 were found in 4, 3, 12 and 1 patient respectively. All patients received intravenous fluid therapy; some received blood products. Four patients received intravenous immunoglobulin, 69 patients were treated with ribavirin. Conclusions: Clinical findings of CCHF in children are similar to those in adults; in patients with low serum immunoglobulin outside the intravenous immunoglobulin (IVIG) treatment, other treatments are similar in all patients. In CCHF to investigate immunodeficiency status, further large-scale study is needed. Keywords Child, immunoglobulin, Crimean-Congo Hemorrhagic Fever, treatment Giris: Calismamizda, Kirim-Kongo Kanamali Atesi (KKKA) tanisiyla izlenen cocuk hastalarin klinik ve rutin laboratuvar bulgulariyla birlikte, serum immunglobulin ve kompleman duzeylerinin degerlendirilmesi amaclandi. Gerec ve Yontem: Sivas, Cumhuriyet Universitesi'nde 2011-2012 tarihleri arasinda, Enzyme-Linked Immunosorbent Assay (ELISA) veya polimeraz zincir reaksiyonu (PCR) kanitli KKKA tanisi alan 72 hastanin tibbi kayitlari geriye donuk incelenmistir. Epidemi