Delayed Consequences of Experimental Myocardial Infarction: Functional Responses to Stimulation of [alpha]2-Adrenoreceptors in the Isolated Heart

We carried out a comparative analysis of the performance of the heart isolated from healthy rats and in 54 and 120 days after modeling of myocardium infarction. On day 120, the blood supply and heart contraction force increased, while HR did not change. Stimulation of [alpha]2-adrenoreceptors with c...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-02, Vol.172 (4), p.419
Main Authors: Kuptsova, A.M, Bugrov, R.K, Ziyatdinova, N.I, Zefirov, T.L
Format: Article
Language:English
Subjects:
Clonidine
Comparative analysis
Dexmedetomidine
Heart attack
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Summary:We carried out a comparative analysis of the performance of the heart isolated from healthy rats and in 54 and 120 days after modeling of myocardium infarction. On day 120, the blood supply and heart contraction force increased, while HR did not change. Stimulation of [alpha]2-adrenoreceptors with clonidine hydrochloride ([10.sup.-9] M) reduced the force and rate of contraction and the blood flow in the isolated heart from healthy rats. Stimulation of [alpha]2-adrenoreceptors of the isolated heart on day 54 after modeling of myocardium infarction induced a positive inotropic response, bradycardia, and insignificant changes in the heart blood flow. On day 120, stimulation of [alpha]2-adrenoreceptors slightly reduced HR and the force of contraction and induced biphasic changes in the coronary flow of the isolated heart. Key Words: [alpha]2-adrenoreceptors; model of myocardial infarction; isolated heart; rat
ISSN:0007-4888
DOI:10.1007/s10517-022-05406-5