Are Inflammatory Bowel Disease and Colorectal Carcinoma Associated with Helicobacter pylori ? A Prospective Study and Meta-analysis

Observational studies regarding the correlation between colorectal carcinoma, inflammatory bowel disease and Helicobacter pylori infection are inconsistent. The present study aims to investigate the association between colorectal adenocarcinoma (CRA) and inflammatory bowel disease (IBD) with H. pylo...

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Published in:Journal of pure & applied microbiology : an international research journal of microbiology 2022-03, Vol.16 (1), p.717
Main Authors: Bouriat, Kaoutar, Cherif, Soumia, Sellami, Souad, Dref, Maria, Krati, Khadija, Meriem, Meftah Elkhir, Elantri, Said, Amine, Abdessamad, Rais, Hanane
Format: Article
Language:English
Subjects:
Analysis
Cancer
Carcinoma
Colorectal cancer
Development and progression
Gastrointestinal diseases
Health aspects
Helicobacter infections
Helicobacter pylori
Immunohistochemistry
Infection
Medical research
Medicine, Experimental
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Summary:Observational studies regarding the correlation between colorectal carcinoma, inflammatory bowel disease and Helicobacter pylori infection are inconsistent. The present study aims to investigate the association between colorectal adenocarcinoma (CRA) and inflammatory bowel disease (IBD) with H. pylori status in 100 patients who have inflammatory bowel disease and colorectal carcinoma was confirmed disease by histological approach. Besides, a meta-analysis was performed of published studies, to evaluate the link between H. pylori infection and an increased risk of CRC and IBD. Among 67 cases with CRA and 33 cases with IBD, 59.7% and 51.5% were H. pylori positive; respectively. In the meta-analysis, thirty-nine articles were included, involving 13 231 cases with CRC and 2477 with IBD. The pooled odds ratio for CRC and IBD was 1.16 (95%CI = 0.73-1.82) and 0.42 (95%CI = 0.32-0.56); respectively. Our meta-analysis indicates that H. pylori is not associated with CRC. Keywords: Colorectal adenocarcinoma, colorectal cancer, Helicobacter pylori, IBD, immunohistochemistry, metaanalysis
ISSN:0973-7510
DOI:10.22207/JPAM.16.L75