Significance of metastamiR-10b in breast cancer therapeutics

Background Breast cancer is a fatal disease and a major reason of cancer associated death in females. Many factors along with miRNA are responsible for the development and the progression of the disease. The miRNA plays a very crucial role in the regulation of the genes. MicroRNAs are of three major...

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Bibliographic Details
Published in:Journal of Egyptian National Cancer Institute 2022-05, Vol.34 (1), p.1-6
Main Authors: Raval, Apexa, Joshi, Jigna, Shah, Franky
Format: Article
Language:English
Subjects:
Breast cancer
Development and progression
Homeopathy
Materia medica and therapeutics
Metastasis
MicroRNA
Stem cells
Therapeutics
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Summary:Background Breast cancer is a fatal disease and a major reason of cancer associated death in females. Many factors along with miRNA are responsible for the development and the progression of the disease. The miRNA plays a very crucial role in the regulation of the genes. MicroRNAs are of three major types-oncomiRs, tumor suppressive miRNAs, and metastamiRs. Main body MicoRNA-10b is a prometastatic microRNA targeting various genes that facilitates multiple outcomes such as metastasis, increased capacity for invasion, proliferation and migration, increased epithelial-mesenchymal transformation, angiogenesis, and therefore exhibits worse clinical outcomes. It is found to be upregulated in various malignancies and is thus to be considered as the possible therapeutic candidate. Conclusion The therapeutic delivery of miR-10b antagonists (antagomiRs) and/or knockdown of miRNA is beneficial in reducing tumor growth. Additionally, combination therapy which includes antisense oligonucleotides using miR-10b can function as an effective approach to tumor regression and drug resistance reversal. Graphical abstract
ISSN:1110-0362
2589-0409
DOI:10.1186/s43046-022-00120-9