Pharmacological Management of Trans and Gender-Diverse Adolescents

Internationally, increasing numbers of children and adolescents with gender dysphoria are presenting for care. In response, gender-affirming therapeutic interventions that seek to align bodily characteristics with an individual's gender identity are more commonly being used. Depending on a youn...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2022-01, Vol.107 (1), p.241
Main Authors: O'Connell, Michele A, Nguyen, Thomas P, Ahler, Astrid, Skinner, S. Rachel, Pang, Ken C
Format: Article
Language:English
Subjects:
Decision-making
Gender identity
Health aspects
Teenagers
Transgender people
Youth
Online Access:Get full text
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Summary:Internationally, increasing numbers of children and adolescents with gender dysphoria are presenting for care. In response, gender-affirming therapeutic interventions that seek to align bodily characteristics with an individual's gender identity are more commonly being used. Depending on a young person's circumstances and goals, hormonal interventions may aim to achieve full pubertal suppression, modulation of endogenous pubertal sex hormone effects, and/or development of secondary sex characteristics congruent with their affirmed gender.This is a relatively novel therapeutic area and, although short-term outcomes are encouraging, longer term data from prospective longitudinal adolescent cohorts are still lacking, which may create clinical and ethical decision-making challenges. Here, we review current treatment options, reported outcomes, and clinical challenges in the pharmacological management of trans and gender-diverse adolescents. Key Words: transgender, gender dysphoria, gender diverse, hormone therapy, adolescents
ISSN:0021-972X
DOI:10.1210/clinem/dgab634