Sublethal toxicity of carbofuran in cattle egret : alteracoes hematologicas, bioquimicas e histopatologicas

• Published in: Brazilian journal of biology 2024-01, Vol.84
• Main Authors: Munir, M.A, Anjum, K.M, Javid, A, Khan, N, Jianming, C, Naseer, J, Anjum, A, Usman, S, Shahzad, M, Hafeez, Shahid, Hussain, T, Saeed, A, Badeni, A.H, Mansoor, M.K, Hussain, I
• Format: Article
• Language: English
• Subjects: Beef cattle; Carbamates; Enzymes; Ethylenediaminetetraacetic acid; Herons; Physiological aspects
• ISSN: 1519-6984
• DOI: 10.1590/1519-6984.255055

This study was aimed to investigate Carbofuran (CF)-induced pathological changes in cattle egret. Two hundred cattle egrets were reared and equally divided into four groups and given different CF concentrations (0.03 mg/L, 0.02 mg/L, 0.01 mg/L and 0 mg/L (control group)). Hematology, serum biochemistry, histopathology, and immunological markers were studied. Our results confirm that CF induces anemic conditions, leukocytosis, elevated liver enzymatic activity, and alterations in renal biomarkers. Moreover, specific microscopic lesions such as multifocal necrosis, pyknotic nuclei, hemorrhages, congestion, and inflammatory cell proliferation were observed in the liver, kidney, spleen, and thymus. These findings suggest that CF can induce harmful effects, so the application of this pesticide in the field must be strictly monitored to mitigate the possibility of exposure to non-target species. Keywords: carbofuran, cattle egret, hematology, serum biochemistry, histopathology. Este estudo teve como objetivo investigar as alteracoes patologicas induzidas por carbofurano (CF) em garcas-vaqueiras. Duzentas dessas garcas foram criadas e divididas igualmente em quatro grupos e receberam diferentes concentracoes de CF: 0,03 mg/L; 0,02 mg/L; 0,01 mg/L; e 0 mg/L (grupo controle). Foram realizadas analises de hematologia, bioquimica serica, histopatologia e marcadores imunologicos. Nossos resultados confirmaram que CF induz condicoes anemicas, leucocitose, atividade enzimatica hepatica elevada e alteracoes nos biomarcadores renais. Alem disso, lesoes microscopicas especificas, como necrose multifocal, nucleos picnoticos, hemorragias, congestao e proliferacao de celulas inflamatorias, foram observadas no figado, rim, baco e timo. Esses achados sugerem que o CF pode causar efeitos nocivos, portanto a aplicacao desse agrotoxico no campo deve ser rigorosamente monitorada para mitigar a possibilidade de exposicao a especies nao alvo. Palavras-chave: carbofurano, garca-vaqueira, hematologia, bioquimica serica, histopatologia.