Gut-derived bacterial toxins impair memory [CD4.sup.+] T cell mitochondrial function in HIV-1 infection

People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their [CD4.sup.+] T cell count after antiretroviral therapy (ART). INRs have low [CD4.sup.+] T cell counts (

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Bibliographic Details
Published in:The Journal of clinical investigation 2022-05, Vol.132 (9)
Main Authors: Ferrari, Brian, Da Silva, Amanda Cabral, Liu, Ken H, Saidakova, Evgeniya V, Korolevskaya, Larisa B, Shmagel, Konstantin V, Shive, Carey, Sanchez, Gabriela Pacheco, Retuerto, Mauricio, Sharma, Ashish Arunkumar, Chneim, Khader, Noel-Romas, Laura, Rodriguez, Benigno, Ghannoum, Mahmoud A, Hunt, Peter P, Deeks, Steven G, Burgener, Adam D, Jones, Dean P, Dobre, Mirela A, Marconi, Vincent C, Sekaly, Rafick-Pierre, Younes, Souheil-Antoine
Format: Article
Language:English
Subjects:
Bacterial toxins
Care and treatment
CD4 lymphocytes
Development and progression
Health aspects
HIV infection
Immune response
Immunologic memory
Immunological research
Microbiota (Symbiotic organisms)
Physiological aspects
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Summary:People living with HIV (PLWH) who are immune nonresponders (INRs) are at greater risk of comorbidity and mortality than are immune responders (IRs) who restore their [CD4.sup.+] T cell count after antiretroviral therapy (ART). INRs have low [CD4.sup.+] T cell counts (
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI149571