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Optimization of Phenolics Extraction from Strobilanthes cusia Leaves and their Antioxidant Activity
Strobilanthes cusia (Nees) Kuntze is commonly used as a traditional medicine with widespread health benefits. This work proposed S. cusia leaves as a potential source of phenolic compounds for extraction and examined the antioxidant capacity of the phenolic-rich extract. Several solvents (ethanol, m...
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| Published in: | Pharmaceutical chemistry journal 2022-06, Vol.56 (3), p.374-380 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c288t-c529f2ab18f8954790aa9053e35b15f174c31a205dfdfc3e293ac205071748433 |
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| cites | cdi_FETCH-LOGICAL-c288t-c529f2ab18f8954790aa9053e35b15f174c31a205dfdfc3e293ac205071748433 |
| container_end_page | 380 |
| container_issue | 3 |
| container_start_page | 374 |
| container_title | Pharmaceutical chemistry journal |
| container_volume | 56 |
| creator | Nguyen, Thi Cam Vi Trinh, Le Thien Tam Nguyen, Khanh Linh Nguyen, Hoang Chinh Tran, Thi Dung |
| description | Strobilanthes cusia
(Nees) Kuntze is commonly used as a traditional medicine with widespread health benefits. This work proposed
S. cusia
leaves as a potential source of phenolic compounds for extraction and examined the antioxidant capacity of the phenolic-rich extract. Several solvents (ethanol, methanol, and water) were screened as extractants. Among these, methanol showed the highest extraction efficiency. Single-factor experiments and response surface methodology were then applied to optimize the extraction conditions. The maximum total phenolic content of 64.86 ± 0.32 mg GAE/g was obtained under the following extraction conditions: extraction time, 2.27 h; methanol-to-material ratio, 9.55 mL/g; aqueous methanol concentration, 63.54%. The phenolic-rich extract showed potential antioxidant capacity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical at an IC
50
value of 464.59 μg/mL. This study shows that
S. cusia
leaves are rich in phenolic constituents and suggests
S. cusia
leaf extracts as promising antioxidant agents for future applications. |
| doi_str_mv | 10.1007/s11094-022-02646-7 |
| format | article |
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(Nees) Kuntze is commonly used as a traditional medicine with widespread health benefits. This work proposed
S. cusia
leaves as a potential source of phenolic compounds for extraction and examined the antioxidant capacity of the phenolic-rich extract. Several solvents (ethanol, methanol, and water) were screened as extractants. Among these, methanol showed the highest extraction efficiency. Single-factor experiments and response surface methodology were then applied to optimize the extraction conditions. The maximum total phenolic content of 64.86 ± 0.32 mg GAE/g was obtained under the following extraction conditions: extraction time, 2.27 h; methanol-to-material ratio, 9.55 mL/g; aqueous methanol concentration, 63.54%. The phenolic-rich extract showed potential antioxidant capacity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical at an IC
50
value of 464.59 μg/mL. This study shows that
S. cusia
leaves are rich in phenolic constituents and suggests
S. cusia
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(Nees) Kuntze is commonly used as a traditional medicine with widespread health benefits. This work proposed
S. cusia
leaves as a potential source of phenolic compounds for extraction and examined the antioxidant capacity of the phenolic-rich extract. Several solvents (ethanol, methanol, and water) were screened as extractants. Among these, methanol showed the highest extraction efficiency. Single-factor experiments and response surface methodology were then applied to optimize the extraction conditions. The maximum total phenolic content of 64.86 ± 0.32 mg GAE/g was obtained under the following extraction conditions: extraction time, 2.27 h; methanol-to-material ratio, 9.55 mL/g; aqueous methanol concentration, 63.54%. The phenolic-rich extract showed potential antioxidant capacity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical at an IC
50
value of 464.59 μg/mL. This study shows that
S. cusia
leaves are rich in phenolic constituents and suggests
S. cusia
leaf extracts as promising antioxidant agents for future applications.</description><subject>Antioxidants</subject><subject>Medicine</subject><subject>Methanol</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phenols</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kFtLAzEQhYMoWC9_wKeAz6uTZNNsHkupFyhUUMG3kGaTNqWblGRb1F9van0RRMIQ5sz5BuYgdEXghgCI20wIyLoCSksN62EljtCAcMEqCYwcowGAJBXh8HaKznJeARSM0QEys03vO_-pex8Djg4_LW2Ia28ynrz3SZtv3aXY4ec-xblf69AvbcZmm73GU6t3pdGhxUX1CY9CAd59W1x4VOCd7z8u0InT62wvf_5z9Ho3eRk_VNPZ_eN4NK0MbZq-MpxKR_WcNK6RvBYStJbAmWV8TrgjojaMaAq8da0zzFLJtCktiDJqasbO0fVh70KvrfLBxf0Bnc9GjQQMhWw4h-K6-cNVXms7b2Kwzhf9F0APgEkx52Sd2iTf6fShCKh9-uqQvirpq-_0lSgQO0C5mMPCJrWK2xTK-f9RX7Jgh4c</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Nguyen, Thi Cam Vi</creator><creator>Trinh, Le Thien Tam</creator><creator>Nguyen, Khanh Linh</creator><creator>Nguyen, Hoang Chinh</creator><creator>Tran, Thi Dung</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220601</creationdate><title>Optimization of Phenolics Extraction from Strobilanthes cusia Leaves and their Antioxidant Activity</title><author>Nguyen, Thi Cam Vi ; Trinh, Le Thien Tam ; Nguyen, Khanh Linh ; Nguyen, Hoang Chinh ; Tran, Thi Dung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-c529f2ab18f8954790aa9053e35b15f174c31a205dfdfc3e293ac205071748433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Medicine</topic><topic>Methanol</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phenols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Thi Cam Vi</creatorcontrib><creatorcontrib>Trinh, Le Thien Tam</creatorcontrib><creatorcontrib>Nguyen, Khanh Linh</creatorcontrib><creatorcontrib>Nguyen, Hoang Chinh</creatorcontrib><creatorcontrib>Tran, Thi Dung</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Thi Cam Vi</au><au>Trinh, Le Thien Tam</au><au>Nguyen, Khanh Linh</au><au>Nguyen, Hoang Chinh</au><au>Tran, Thi Dung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimization of Phenolics Extraction from Strobilanthes cusia Leaves and their Antioxidant Activity</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2022-06-01</date><risdate>2022</risdate><volume>56</volume><issue>3</issue><spage>374</spage><epage>380</epage><pages>374-380</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>Strobilanthes cusia
(Nees) Kuntze is commonly used as a traditional medicine with widespread health benefits. This work proposed
S. cusia
leaves as a potential source of phenolic compounds for extraction and examined the antioxidant capacity of the phenolic-rich extract. Several solvents (ethanol, methanol, and water) were screened as extractants. Among these, methanol showed the highest extraction efficiency. Single-factor experiments and response surface methodology were then applied to optimize the extraction conditions. The maximum total phenolic content of 64.86 ± 0.32 mg GAE/g was obtained under the following extraction conditions: extraction time, 2.27 h; methanol-to-material ratio, 9.55 mL/g; aqueous methanol concentration, 63.54%. The phenolic-rich extract showed potential antioxidant capacity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical at an IC
50
value of 464.59 μg/mL. This study shows that
S. cusia
leaves are rich in phenolic constituents and suggests
S. cusia
leaf extracts as promising antioxidant agents for future applications.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-022-02646-7</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | Springer Nature |
| subjects | Antioxidants Medicine Methanol Organic Chemistry Pharmacology/Toxicology Pharmacy Phenols |
| title | Optimization of Phenolics Extraction from Strobilanthes cusia Leaves and their Antioxidant Activity |
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