Synthesis and Antiproliferative Activity of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles

A series of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles were synthesized. Their antiproliferative activity was studied. Substituents in the pyridine ring 5- and 6-positions influenced the activity of the molecules. 2-Oxo-2,5,6,7-tetrahydro-1 H -cyclopenta[ b ]pyridine-3,4-dicarbonitrile and 2-oxo-...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2022-06, Vol.56 (3), p.325-328
Main Authors: Fedoseev, S. V., Lipin, K. V., Ershov, O. V.
Format: Article
Language:English
Subjects:
Colon cancer
Leukemia
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Prostate cancer
Pyridine
Resveratrol
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Summary:A series of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles were synthesized. Their antiproliferative activity was studied. Substituents in the pyridine ring 5- and 6-positions influenced the activity of the molecules. 2-Oxo-2,5,6,7-tetrahydro-1 H -cyclopenta[ b ]pyridine-3,4-dicarbonitrile and 2-oxo-6- tert -butyl-1,2,5,6,7,8-hexahydroquinoline-3,4-dicarbonitrile slightly inhibited the growth of leukemia (with a tendency to a greater degree for K-562 and SR), brain cancer (with a tendency to a greater degree for SNB-75), prostate cancer (with a tendency to a greater degree of PC-3), and breast cancer cell lines (with a tendency to a greater degree for MCF-7).
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-022-02638-7