IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease

Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses.

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Bibliographic Details
Published in:Journal of Clinical Investigation 2022, Vol.132 (12)
Main Authors: Dwyer, Gaelen K, Mathews, Lisa R, Villegas, Jose A, Lucas, Anna, de Peredo, Anne Gonzalez, Blazar, Bruce R, Girard, Jean-Philippe, Poholek, Amanda C, Luther, Sanjiv A, Shlomchik, Warren, Turnquist, Heth R
Format: Report
Language:English
Subjects:
Antigen presenting cells
Care and treatment
Cellular signal transduction
Development and progression
Graft versus host reaction
Health aspects
Hematopoietic stem cells
Immunological research
Interleukins
Physiological aspects
Stem cells
T cells
Transplantation
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Description
Summary:Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses.
ISSN:0021-9738
DOI:10.1172/JCI150927