The Role of Milk Protein and Whey Permeate in Lipid-based Nutrient Supplements on the Growth and Development of Stunted Children in Uganda: A Randomized Trial Protocol

Stunting is associated with cognitive impairment and later chronic disease. Previous trials to prevent stunting have had little effect, and no trials seem to have provided larger amounts of energy and high-quality proteins to already stunted children. We aimed to assess the effects of milk protein (...

Full description

Saved in:
Bibliographic Details
Published in:Current developments in nutrition 2021-05, Vol.5 (5), p.1
Main Authors: Pesu, Hannah, Mutumba, Rolland, Mbabazi, Joseph, Olsen, Mette F, Molgaard, Christian, Michaelsen, Kim F, Ritz, Christian, Filteau, Suzanne, Briend, Andre, Mupere, Ezekiel, Friis, Henrik, Grenov, Benedikte
Format: Article
Language:English
Subjects:
Care and treatment
Growth disorders
Health aspects
Lipids
Milk proteins
Pediatric research
Whey
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stunting is associated with cognitive impairment and later chronic disease. Previous trials to prevent stunting have had little effect, and no trials seem to have provided larger amounts of energy and high-quality proteins to already stunted children. We aimed to assess the effects of milk protein (MP) and whey permeate (WP) in large-quantity lipid-based nutrient supplements (LNS-LQ), among stunted children, on linear growth and child development. This was a randomized, double-blind, 2-by-2 factorial trial. Stunted children aged 12-59 mo from eastern Uganda (n = 750) were randomly assigned to receive 100 g LNS-LQ with or without MP and WP (n = 4 X 150) or no supplement (n = 150) for3 mo. The primary outcomes were change in knee-heel and total length. Secondary outcomes included child development, body composition, anthropometry, and hemoglobin. Micronutrient status, intestinal function, and microbiota were also assessed. Our findings will contribute to an understanding of the role of milk ingredients and LNS in linear catch-up growth. This trial was registered at www.isrctn.com as ISRCTN13093195. Curr Dev Nutr 2021;5:nzab067. Keywords: stunting, linear growth, lipid-based nutrient supplement (LNS), milk protein, whey permeate, child development, body composition, gut
ISSN:2475-2991
2475-2991