Evaluation of nuclear factor E2-related factor 2 in patients with alopecia areata: a relation with systemic oxidative stress

Background Alopecia areata (AA) is a common dermatologic disease with autoimmune etiology. Systemic and tissue oxidative stresses are present in AA. Nuclear factor-E2-related factor 2 (Nrf2) is a transcription factor that stimulates transcription of antioxidant genes. Objective To investigate the ro...

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Bibliographic Details
Published in:Journal of the Egyptian women's dermatologic society 2022-05, Vol.19 (2), p.100-107
Main Authors: Bakry, Ola, El Hefnawy, Sally, El Naggar, Doha, Seleit, Iman
Format: Article
Language:English
Subjects:
Alopecia
Analysis
Antioxidants
Baldness
Development and progression
Genetic aspects
Oxidative stress
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Summary:Background Alopecia areata (AA) is a common dermatologic disease with autoimmune etiology. Systemic and tissue oxidative stresses are present in AA. Nuclear factor-E2-related factor 2 (Nrf2) is a transcription factor that stimulates transcription of antioxidant genes. Objective To investigate the role of Nrf2 in systemic oxidative stress in AA. Patients and methods A case-control study was designed. A total of 30 cases with AA and 30 age-matched and sex-matched healthy participants were included. Cases were diagnosed clinically and by dermoscopy and evaluated according to the severity of the alopecia tool score. Nrf2, total oxidant capacity (TOC), and total antioxidant capacity (TAC) were measured by enzyme-linked immunosorbent assay, and the oxidative stress index (OSI) was calculated. Results Serum Nrf2 and TAC were significantly lower in AA than the control group (P
ISSN:1687-1537
2090-2565
DOI:10.4103/jewd.jewd_61_21