Eccentric Enlargement of the Aortic Sinuses in Pediatric and Adult Patients with Bicuspid Aortic Valves: A Cardiac MRI Study

Aortic root size and cusp fusion pattern have been related to disease outcomes in bicuspid aortic valve (BAV). This study seeks to characterize symmetry of the aortic sinuses in adult and pediatric BAV patients and its relationship to valvulopathy and root aortopathy. Aortic sinus-to-commissure (S-C...

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Bibliographic Details
Published in:Pediatric cardiology 2020-02, Vol.41 (2), p.350-360
Main Authors: Stefek, Heather A., Lin, Kevin H., Rigsby, Cynthia K., Michelena, Hector I., Aouad, Pascale, Barker, Alex J., Robinson, Joshua D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aorta - diagnostic imaging
Aorta - pathology
Aortic Valve - abnormalities
Aortic Valve - diagnostic imaging
Aortic Valve - pathology
Bicuspid Aortic Valve Disease
Cardiac Surgery
Cardiology
Child
Epidemiology
Female
Gadobutrol
Gadofosveset
Heart valve diseases
Heart Valve Diseases - etiology
Heart Valve Diseases - pathology
Humans
Magnetic Resonance Imaging
Male
Medical imaging equipment
Medicine
Medicine & Public Health
Middle Aged
Original Article
Pediatrics
Retrospective Studies
Sinus of Valsalva - diagnostic imaging
Sinus of Valsalva - pathology
Vascular Surgery
Young Adult
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Summary:Aortic root size and cusp fusion pattern have been related to disease outcomes in bicuspid aortic valve (BAV). This study seeks to characterize symmetry of the aortic sinuses in adult and pediatric BAV patients and its relationship to valvulopathy and root aortopathy. Aortic sinus-to-commissure (S-C) lengths were measured on cardiac MRI of adult and pediatric BAV patients with right-and-left coronary (RL) or right-and-non-coronary (RN) leaflet fusion and tricuspid aortic valve (TAV) controls. Coefficient of variance (CoV) of S-C lengths was calculated to quantify sinus asymmetry, or eccentricity. BAV cohort included 149 adults (48 ± 15 years) and 51 children (15 ± 5 years). TAV cohort included 40 adults (60 ± 13 years) and 20 children (15 ± 5 years). In adult and pediatric BAV patients, the non-fused aortic sinus was larger than either fused sinus. In RL fusion, the non-coronary S-C distance was larger than right or left S-C distances in adults ( n  = 121, p  
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-019-02264-3