"Specific Antibodies to the Fragments of Meningococcal IgAl Protease during the Formation of Immunity to Bacterial Infections."

The features of individual fragments of IgA1 protease of Neisseria meningitidis serogroup B during the formation of immunity to bacterial infections in animals and humans were studied. The antibodies to the immunogenic regions of the studied proteins are also detected in mice infected with some bact...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2022-09, Vol.173 (5), p.687
Main Authors: Kotel'nikova, O.V, Prokopenko, Yu.A, Zinchenko, A.A, Razgulyaeva, O.A, Nokel', E.A, Karlinsky, D.M, Zhigis, L.S, Rumsh, L.D
Format: Article
Language:English
Subjects:
Bacterial infections
Health aspects
Immune response
Immunoglobulin A
Medical research
Medicine, Experimental
Meningitis
Proteases
Recombinant proteins
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Summary:The features of individual fragments of IgA1 protease of Neisseria meningitidis serogroup B during the formation of immunity to bacterial infections in animals and humans were studied. The antibodies to the immunogenic regions of the studied proteins are also detected in mice infected with some bacterial pathogens and in humans with bacterial meningitis. A region of IgAl protease was identified that is not capable of producing antibodies during immunization of animals, but that detects homologous antibodies in the blood of humans and animals recovered from bacterial infections. It has been suggested that this fragment plays a regulatory role in the process of immunogenesis. Key Words: IgAl protease; recombinant proteins; immunogenicity; bacterial infections
ISSN:0007-4888
DOI:10.1007/s10517-022-05614-z