Effect of Low Dietary Vitamin D Fed Prior to and During Pregnancy and Lactation on Maternal Bone Mineral Density, Structure, and Strength in C57BL/6 Mice

Several studies have shown that diets containing lower vitamin D than in the AIN-93G diet do not compromise bone structure, bone mineral density (BMD), and/or bone strength in male and female mice. This study determined if a diet containing low vitamin D from prepregnancy through to the end of lacta...

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Bibliographic Details
Published in:Current developments in nutrition 2021-10, Vol.5 (10), p.1
Main Authors: Villa, Christopher R, Sacco, Sandra M, Chen, Jianmin, Taibi, Amel, Comelli, Elena M, Ward, Wendy E
Format: Article
Language:English
Subjects:
Alfacalcidol
Bones
Calcifediol
Density
Diet
Food and nutrition
Health aspects
Lactation
Physiological aspects
Pregnancy
Vitamin D
Women
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Summary:Several studies have shown that diets containing lower vitamin D than in the AIN-93G diet do not compromise bone structure, bone mineral density (BMD), and/or bone strength in male and female mice. This study determined if a diet containing low vitamin D from prepregnancy through to the end of lactation maintained these bone outcomes to a similar extent as a high vitamin D diet. Mice were fed an AIN-93G diet with 25 (LD diet) or 5000 (HD diet) IU vitamin D/kg diet from premating through to lactation (n = 15/group). Of the major structure outcomes, only cortical area fraction of the distal femur was lower (P
ISSN:2475-2991
2475-2991