Phosphorus-Containing Aminocarboxylic Acids: XV. [alpha],[omega]-Diamino-[omega],[omega]-diphosphonoalkylcarboxylic Acids

A general method for the synthesis of phosphonic aminocarboxylic acids combining aminodiphosphonic and amino acid functions in one molecule was developed. Amino acids of a new type are AP-acids analogs, which are ligands of glutamate receptors that determine the processes of information transmission...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of general chemistry 2018-05, Vol.88 (5), p.1045
Main Author: Ragulin, V.V
Format: Article
Language:English
Subjects:
Amino acids
Esters
Glutamate
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A general method for the synthesis of phosphonic aminocarboxylic acids combining aminodiphosphonic and amino acid functions in one molecule was developed. Amino acids of a new type are AP-acids analogs, which are ligands of glutamate receptors that determine the processes of information transmission and processing in the central nervous system, and can also be promising compounds as new components of radiopharmaceuticals. Keywords: [omega]-cyanoalkylacetamidomalonic esters, [omega]-amino-[omega],[omega]-diphosphonoalkylacetamidomalomc esters, [alpha],[omega]-diamino-[omega],[omega]-diphosphonic acids, radiopharmaceuticals, glutamate receptors
ISSN:1070-3632
DOI:10.1134/S1070363218050341