An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[-diones and Their Antimicrobial Activity

The Buchwald-Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4aminophenyl)-1H- benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd[([PPh.sub.3]).sub.4] and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradia...

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Published in:Russian journal of general chemistry 2018-04, Vol.88 (4), p.780
Main Authors: Sakram, B, Ravi, D, Rambabu, K. Ashok S, Sonyanaik, B, Kurumanna, A
Format: Article
Language:English
Subjects:
Amino acids
Antibacterial agents
Nuclear magnetic resonance spectroscopy
Palladium
Palladium catalysts
Urinary tract infections
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container_title Russian journal of general chemistry
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Ravi, D
Rambabu, K. Ashok S
Sonyanaik, B
Kurumanna, A
description The Buchwald-Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4aminophenyl)-1H- benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd[([PPh.sub.3]).sub.4] and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)- diones. Structures of the synthesized compounds were evaluated by IR, [sup.1]H and [sup.13]C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus. Keywords: Antimicrobial activity, C-N bond formation, microwave irradiation, molecular docking, 1,8-naphthyridine, Pd[([PPh.sub.3]).sub.4] catalyst DOI: 10.1134/S1070363218040242
doi_str_mv 10.1134/S1070363218040242
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subjects Amino acids
Antibacterial agents
Nuclear magnetic resonance spectroscopy
Palladium
Palladium catalysts
Urinary tract infections
title An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[-diones and Their Antimicrobial Activity
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