Comparison of Selenium-Enriched ILactobacillus/I Iparacasei/I, Selenium-Enriched Yeast, and Selenite for the Alleviation of DSS-Induced Colitis in Mice

• Published in: Nutrients 2022-06, Vol.14 (12)
• Main Authors: Zhong, Yuqing, Jin, Yan, Zhang, Qiuxiang, Mao, Bingyong, Tang, Xin, Huang, Jie, Guo, Renmei, Zhao, Jianxin, Cui, Shumao, Chen, Wei
• Format: Article
• Language: English
• Subjects: Care and treatment; Colitis; Dietary supplements; Lactobacillus; Probiotics; Selenite; Testing; Yeast
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14122433

Patients with inflammatory bowel disease (IBD) have been found to have decreased immune function. Selenium (Se) is an essential trace element that is beneficial for human health, which has a significant stimulating effect on immune function. We compared the effects of different Se forms on the alleviation of colitis in DSS-induced mice. Moreover, we also aimed to determine whether Se-enriched Lactobacillus paracasei CCFM 1089 could be used as a new organic Se supplement. Different Se supplements (Se-enriched L. paracasei CCFM 1089, Se-enriched yeast and sodium selenite) were given to Se-deficient mice suffering from colitis. Se-enriched L. paracasei CCFM 1089, which is based on selenocysteine (SeCys), had similar effects in terms of reducing oxidative stress and inhibiting pro-inflammatory factors to Se-enriched yeast; however, selenase activity in the Se-enriched L. paracasei CCFM 1089-treated mice was higher than that in other treatment groups. In addition, Se-enriched L. paracasei CCFM 1089 could better protect the intestinal mucosa, which increased the expression of tight junction proteins (ZO-1 and occludin) in mice. Thus Se-enriched L. paracasei CCFM 1089 was shown to alleviate IBD, suggesting that it has potential as a good organic Se supplement.