Total fat and alpha-tocopherol in breast milk: is there a relationship after supplementation with vitamin E?/Lipideos totais e alfa-tocoferol no leite maduro: existe relacao apos suplementacao com vitamina E?

Introduction: Fat intake during lactation may modify the concentration of vitamin E in human milk, probably because both nutrients are fat soluble and also share similar pathways of distribution, metabolism and molecular action. It is known that the high maternal vitamin E intake through supplementa...

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Published in:Demetra: Alimentação, Nutrição e Saúde Nutrição e Saúde, 2022-01, Vol.17, p.1
Main Authors: de Medeiros, Juliane Oliveira, de Sousa Reboucas, Amanda, Dimenstein, Roberto, da Silva Ribeiro Rodrigues, Karla Danielly
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Dimenstein, Roberto
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description Introduction: Fat intake during lactation may modify the concentration of vitamin E in human milk, probably because both nutrients are fat soluble and also share similar pathways of distribution, metabolism and molecular action. It is known that the high maternal vitamin E intake through supplementation alters alpha-tocopherol concentration in breast milk, but the relationship with human milk lipids has not yet been studied. Objective: This study aims to evaluate the association between alpha-tocopherol and total fat in breast milk after maternal supplementation with megadoses of vitamin E. Method: This study is part of a clinical trial composed of lactating women from a public outpatient clinic in the city of Natal, RN, Brasil. The group studied were 26 lactating women from a supplemented group whom were given a single dose of 800 IU of RRR-alpha-tocopherol (588 mg) between 30 and 90 days postpartum. Breast milk was collected before and 24h after supplementation. The food intake was assessed by a 24-hour Dietary Recall, the concentration of alpha-tocopherol was determined by high-performance liquid chromatography, and lipid concentration was determined by a creamatocrit analyzer. Results: All participants had inadequate vitamin intake (
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It is known that the high maternal vitamin E intake through supplementation alters alpha-tocopherol concentration in breast milk, but the relationship with human milk lipids has not yet been studied. Objective: This study aims to evaluate the association between alpha-tocopherol and total fat in breast milk after maternal supplementation with megadoses of vitamin E. Method: This study is part of a clinical trial composed of lactating women from a public outpatient clinic in the city of Natal, RN, Brasil. The group studied were 26 lactating women from a supplemented group whom were given a single dose of 800 IU of RRR-alpha-tocopherol (588 mg) between 30 and 90 days postpartum. Breast milk was collected before and 24h after supplementation. The food intake was assessed by a 24-hour Dietary Recall, the concentration of alpha-tocopherol was determined by high-performance liquid chromatography, and lipid concentration was determined by a creamatocrit analyzer. Results: All participants had inadequate vitamin intake (&lt;16mg). Alpha-tocopherol concentration in milk increased from 294.8 [micro]g/dL to 631.6 [micro]g/dL after supplementation (p = 0.002). No relationship was found between alpha-tocopherol and total fat in breast milk before and after RRR-alpha-tocopherol supplementation. Conclusion: Therefore, vitamin E supplementation did not show a relationship between alpha-tocopherol and total fat in breast milk. Keywords: Lactation. Fatty acids. Food intake. Nutrient supplementation. Introducao: O consumo de lipideos durante a lactacao pode alterar a concentracao de vitamina E do leite materno, provavelmente, por ambos os nutrientes possuirem carater lipossoluvel e compartilharem vias similares de distribuicao, metabolismo e acao molecular. Sabe-se que o alto consumo materno de vitamina E via suplementacao altera a concentracao de alfa-tocoferol no leite, porem ainda nao foi estudado se essa suplementacao afetaria a quantidade de lipideos do leite. Objetivo: Avaliar a associacao entre as concentracoes de alfa-tocoferol e de lipideos totais no leite materno apos suplementacao materna com megadose de vitamina E. Metodo: O presente estudo e parte de um ensaio clinico randomizado, composto por lactantes atendidas em ambulatorio publico de Natal-RN. O recorte foi realizado com 26 lactantes do grupo suplementado, as quais receberam dose unica de 800 UI de RRR-alfa-tocoferol (588 mg) entre 30 e 90 dias pos-parto, sendo coletado leite antes e 24h apos a suplementacao. O consumo alimentar foi obtido pelo recordatorio de 24h, o alfa-tocoferol foi analisado por cromatografia liquida de alta eficiencia e a concentracao de lipideo foi determinada por crematocrito. Resultados: Todas as mulheres apresentaram consumo inadequado de vitamina E (&lt;16mg). A concentracao de alfa-tocoferol no leite aumentou de 294,8 [micro]g/dL para 631,6 [micro]g/dL apos a suplementacao (p = 0,002), e nao foi encontrada relacao entre o alfa-tocoferol e lipideos totais no leite antes e apos a suplementacao. Conclusao: A suplementacao de vitamina E nao evidenciou relacao entre alfa-tocoferol e lipideos totais no leite materno. Palavras-chave: Lactacao. Acidos Graxos. Consumo Alimentar. Suplementacao alimentar-</description><identifier>ISSN: 2238-913X</identifier><identifier>EISSN: 2238-913X</identifier><identifier>DOI: 10.12957/demetra.2022.65415</identifier><language>por</language><publisher>Universidade do Estado do Rio de Janeiro- Uerj</publisher><ispartof>Demetra: Alimentação, Nutrição e Saúde, 2022-01, Vol.17, p.1</ispartof><rights>COPYRIGHT 2022 Universidade do Estado do Rio de Janeiro- Uerj</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>de Medeiros, Juliane Oliveira</creatorcontrib><creatorcontrib>de Sousa Reboucas, Amanda</creatorcontrib><creatorcontrib>Dimenstein, Roberto</creatorcontrib><creatorcontrib>da Silva Ribeiro Rodrigues, Karla Danielly</creatorcontrib><title>Total fat and alpha-tocopherol in breast milk: is there a relationship after supplementation with vitamin E?/Lipideos totais e alfa-tocoferol no leite maduro: existe relacao apos suplementacao com vitamina E?</title><title>Demetra: Alimentação, Nutrição e Saúde</title><description>Introduction: Fat intake during lactation may modify the concentration of vitamin E in human milk, probably because both nutrients are fat soluble and also share similar pathways of distribution, metabolism and molecular action. It is known that the high maternal vitamin E intake through supplementation alters alpha-tocopherol concentration in breast milk, but the relationship with human milk lipids has not yet been studied. Objective: This study aims to evaluate the association between alpha-tocopherol and total fat in breast milk after maternal supplementation with megadoses of vitamin E. Method: This study is part of a clinical trial composed of lactating women from a public outpatient clinic in the city of Natal, RN, Brasil. The group studied were 26 lactating women from a supplemented group whom were given a single dose of 800 IU of RRR-alpha-tocopherol (588 mg) between 30 and 90 days postpartum. Breast milk was collected before and 24h after supplementation. The food intake was assessed by a 24-hour Dietary Recall, the concentration of alpha-tocopherol was determined by high-performance liquid chromatography, and lipid concentration was determined by a creamatocrit analyzer. Results: All participants had inadequate vitamin intake (&lt;16mg). Alpha-tocopherol concentration in milk increased from 294.8 [micro]g/dL to 631.6 [micro]g/dL after supplementation (p = 0.002). No relationship was found between alpha-tocopherol and total fat in breast milk before and after RRR-alpha-tocopherol supplementation. Conclusion: Therefore, vitamin E supplementation did not show a relationship between alpha-tocopherol and total fat in breast milk. Keywords: Lactation. Fatty acids. Food intake. Nutrient supplementation. Introducao: O consumo de lipideos durante a lactacao pode alterar a concentracao de vitamina E do leite materno, provavelmente, por ambos os nutrientes possuirem carater lipossoluvel e compartilharem vias similares de distribuicao, metabolismo e acao molecular. Sabe-se que o alto consumo materno de vitamina E via suplementacao altera a concentracao de alfa-tocoferol no leite, porem ainda nao foi estudado se essa suplementacao afetaria a quantidade de lipideos do leite. Objetivo: Avaliar a associacao entre as concentracoes de alfa-tocoferol e de lipideos totais no leite materno apos suplementacao materna com megadose de vitamina E. Metodo: O presente estudo e parte de um ensaio clinico randomizado, composto por lactantes atendidas em ambulatorio publico de Natal-RN. O recorte foi realizado com 26 lactantes do grupo suplementado, as quais receberam dose unica de 800 UI de RRR-alfa-tocoferol (588 mg) entre 30 e 90 dias pos-parto, sendo coletado leite antes e 24h apos a suplementacao. O consumo alimentar foi obtido pelo recordatorio de 24h, o alfa-tocoferol foi analisado por cromatografia liquida de alta eficiencia e a concentracao de lipideo foi determinada por crematocrito. Resultados: Todas as mulheres apresentaram consumo inadequado de vitamina E (&lt;16mg). A concentracao de alfa-tocoferol no leite aumentou de 294,8 [micro]g/dL para 631,6 [micro]g/dL apos a suplementacao (p = 0,002), e nao foi encontrada relacao entre o alfa-tocoferol e lipideos totais no leite antes e apos a suplementacao. Conclusao: A suplementacao de vitamina E nao evidenciou relacao entre alfa-tocoferol e lipideos totais no leite materno. Palavras-chave: Lactacao. Acidos Graxos. Consumo Alimentar. 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It is known that the high maternal vitamin E intake through supplementation alters alpha-tocopherol concentration in breast milk, but the relationship with human milk lipids has not yet been studied. Objective: This study aims to evaluate the association between alpha-tocopherol and total fat in breast milk after maternal supplementation with megadoses of vitamin E. Method: This study is part of a clinical trial composed of lactating women from a public outpatient clinic in the city of Natal, RN, Brasil. The group studied were 26 lactating women from a supplemented group whom were given a single dose of 800 IU of RRR-alpha-tocopherol (588 mg) between 30 and 90 days postpartum. Breast milk was collected before and 24h after supplementation. The food intake was assessed by a 24-hour Dietary Recall, the concentration of alpha-tocopherol was determined by high-performance liquid chromatography, and lipid concentration was determined by a creamatocrit analyzer. Results: All participants had inadequate vitamin intake (&lt;16mg). Alpha-tocopherol concentration in milk increased from 294.8 [micro]g/dL to 631.6 [micro]g/dL after supplementation (p = 0.002). No relationship was found between alpha-tocopherol and total fat in breast milk before and after RRR-alpha-tocopherol supplementation. Conclusion: Therefore, vitamin E supplementation did not show a relationship between alpha-tocopherol and total fat in breast milk. Keywords: Lactation. Fatty acids. Food intake. Nutrient supplementation. Introducao: O consumo de lipideos durante a lactacao pode alterar a concentracao de vitamina E do leite materno, provavelmente, por ambos os nutrientes possuirem carater lipossoluvel e compartilharem vias similares de distribuicao, metabolismo e acao molecular. Sabe-se que o alto consumo materno de vitamina E via suplementacao altera a concentracao de alfa-tocoferol no leite, porem ainda nao foi estudado se essa suplementacao afetaria a quantidade de lipideos do leite. Objetivo: Avaliar a associacao entre as concentracoes de alfa-tocoferol e de lipideos totais no leite materno apos suplementacao materna com megadose de vitamina E. Metodo: O presente estudo e parte de um ensaio clinico randomizado, composto por lactantes atendidas em ambulatorio publico de Natal-RN. O recorte foi realizado com 26 lactantes do grupo suplementado, as quais receberam dose unica de 800 UI de RRR-alfa-tocoferol (588 mg) entre 30 e 90 dias pos-parto, sendo coletado leite antes e 24h apos a suplementacao. O consumo alimentar foi obtido pelo recordatorio de 24h, o alfa-tocoferol foi analisado por cromatografia liquida de alta eficiencia e a concentracao de lipideo foi determinada por crematocrito. Resultados: Todas as mulheres apresentaram consumo inadequado de vitamina E (&lt;16mg). A concentracao de alfa-tocoferol no leite aumentou de 294,8 [micro]g/dL para 631,6 [micro]g/dL apos a suplementacao (p = 0,002), e nao foi encontrada relacao entre o alfa-tocoferol e lipideos totais no leite antes e apos a suplementacao. Conclusao: A suplementacao de vitamina E nao evidenciou relacao entre alfa-tocoferol e lipideos totais no leite materno. Palavras-chave: Lactacao. Acidos Graxos. Consumo Alimentar. Suplementacao alimentar-</abstract><pub>Universidade do Estado do Rio de Janeiro- Uerj</pub><doi>10.12957/demetra.2022.65415</doi></addata></record>
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title Total fat and alpha-tocopherol in breast milk: is there a relationship after supplementation with vitamin E?/Lipideos totais e alfa-tocoferol no leite maduro: existe relacao apos suplementacao com vitamina E?
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