ASSESSMENT OF UMBILICAL CORD TSH LEVELS IN SMALL FOR GESTATIONAL AGE NEONATES

Background: Small for gestational age (SGA) neonates are born as a result of Intrauterine Growth Retardation (IUGR). This may result due to complex factors of fetal, placental and maternal origin. Thyroid hormones are critical for growth and development of the fetus. It may permanently influence the...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.27 (S1), p.S71
Main Authors: Padwal, M.K, Kamble, B.D, Melinkeri, R.R, Suryawanshi, P.B
Format: Article
Language:English
Subjects:
Analysis
Glycoproteins
Infants (Newborn)
Pituitary hormones
Thyroid diseases
Thyroid hormones
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Summary:Background: Small for gestational age (SGA) neonates are born as a result of Intrauterine Growth Retardation (IUGR). This may result due to complex factors of fetal, placental and maternal origin. Thyroid hormones are critical for growth and development of the fetus. It may permanently influence the endocrine system by affecting its programming during development. Objectives: The present study was a prospective cross-sectional cohort study, designed to assess Umbilical cord Thyroid Stimulating Hormone (TSH) levels in a term small for gestational age neonates. Material and Methods: A group of term babies delivered to eu-thyroid mothers was selected from a tertiary care teaching hospital. It was subdivided into cases (SGA neonates with birth weight [less than or equal to] 2.5 kg, n=58) and control (Average for gestational age neonates (AGA) with birth weight [greater than or equal to] 2.5 kg, n=66). Umbilical cord TSH levels were measured in SGA and AGA neonates by chemiluminescence immunoassay system. Results: There was statistically significant rise in cord TSH levels in SGA neonates as compared to AGA (P=0.001). Conclusions: The finding of higher TSH concentration in a term SGA neonates suggests that there may be intrauterine reprogramming of TSH sensitivity at the hypothalamic pituitary level. However a larger survey with an appropriate follow-up is required to evaluate the prevalence and degree of thyroid dysfunction in children born in a term SGA. Keywords: Small for Gestational Age, IUGR, TSH.
ISSN:0970-1915