Microalbumiuria as a Marker of Renal Complications in Type 2 Diabetes Mellitus

• Published in: Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S98
• Main Authors: Sinha, Nishita, Thimmaraju, K.V, Dwivedi, K.K, Das, Biswajit, Mallick, Ayaz K, Samantha, Sumeru, Saxena, Shikha
• Format: Article
• Language: English
• Subjects: Complications and side effects; Development and progression; Diabetic nephropathies; Diabetics; Enzyme inhibitors; Type 2 diabetes
• ISSN: 0970-1915

Departments of *Biochemistry and Medicine, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India Diabetes mellitus is a stage of persistent hyperglycemia due to absolute or relative deficiency of insulin. About 20-40% of patients with type 2 diabetes mellitus develop diabetic nephropathy. The earliest clinically detectable sign of nephopathy is microalbuminuria. Microalbuminuria is defined as urinary excretion of albumin of 20-200 [micro]g/min or 30-300 mg/ 24 hrs or 30-300 mg/g of creatinine with a negative dipstick test. Prevalence of microalbuminuria and its association with various biochemical parameters. The study was carried out on 100 controls and 100 known cases of type 2 diabetes mellitus of duration more than six month in Biochemistry Department. Patient' s age, gender, duration of diabetes, levels of fasting plasma glucose (FPG), serum urea, serum creatinine and glycosylated hemoglobin (HbA1c) were estimated. The prevalence of microalbuminuria in our present study was found to be 48%. The patients with higher HbAlc and FPG level had high incidence of microalbuminuria as compare to controls (P