Study of Trace Elements in Liver Cirrhosis Patients and their Role in Prognosis of Disease

The aim was to evaluate trace elements in patients with Liver Cirrhosis and assess their association with severity of the disease. 150 Cirrhotic subjects of either sex ranging in age from 20-70 years (mean [+ or -] SD 44.04 [+ or -] 8.57 years) were included in the study and the results were compare...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S130
Main Authors: Nangliya, Vijay Laxmi, Sharma, Anjali, Yadav, Dharamveer, Sunder, Shyam, Nijhawan, Sandeep, Mishra, Shandhya
Format: Article
Language:English
Subjects:
Analysis
Development and progression
Liver cirrhosis
Medical research
Medicine, Experimental
Prognosis
Zinc in the body
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Summary:The aim was to evaluate trace elements in patients with Liver Cirrhosis and assess their association with severity of the disease. 150 Cirrhotic subjects of either sex ranging in age from 20-70 years (mean [+ or -] SD 44.04 [+ or -] 8.57 years) were included in the study and the results were compared with 50, age (mean [+ or -] SD 43.14 [+ or -] 9.37 years) and sex matched healthy control subjects. All Cirrhotic subjects were assessed for severity of disease as Mild (Child A), Moderate (Child B) and Severe (Child C) as per Child Pugh classification. Routine investigations were done and trace elements were analyzed on Atomic Absorption Spectrophotometer. Serum level of Copper content was found significantly increased in Cirrhotic patients as compared to control group. Whereas Serum Zinc, Selenium and Magnesium levels were significantly decreased in Cirrhotic subjects as compared to healthy Controls. Trace elements were compared with severity of liver cirrhosis. Serum Copper concentration was slightly increased in patients with more severe clinical state of liver cirrhosis, however mean level difference of Copper among the Child Pugh groups were statistically not significant. Moreover there was no significant correlation between Copper and Child Pugh Score. However Copper showed a significant negative correlation with Zinc. The Serum Zinc, Magnesium and Selenium levels were significantly decreased with advancement of liver disease (Child B and C) as compared to early stage of liver cirrhosis and showed a significant negative correlation with Child Pugh Score. Micronutrients supplementation in liver cirrhotic patient can prevent progression of disease and development of complications.
ISSN:0970-1915