Relationship Between Body Iron Status and Cardiovascular Risk Factors in Patients with Coronary Artery Disease

Iron is an essential trace element. It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S141
Main Authors: Chopra, Sunny, Lal, A.K, Dhar, Meenakshi, Vij, C
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiac patients
Coronary heart disease
Development and progression
Enzymes
Ferritin
Medical research
Medicine, Experimental
Risk factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Iron is an essential trace element. It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and total iron binding capacity (TIBC) in the causation of coronary artery disease (CAD). The study group consisted of 40 angiographically confirmed cases of CAD and 40 normal healthy controls taken from HIMS, Dehradun. The blood samples were taken after 10-12 hours of fasting. Serum lipids, serum lipoproteins, serum iron and TIBC were estimated by autoanalyzer (Dxc 900 Beckman Coulter). Serum ferritin was measured on Mini VIDAS and MDA was being done by Thiobarbituric acid method. The ratio of Total cholesterol and HDL was significantly raised in CAD patients (5.07) than controls (3.48). The levels of MDA were high in patients (19.9 + 1.7 pmol/l) as compared to controls (4.9 + 1.0 pmol/l). Serum iron and Serum ferritin levels were significantly high in patients with CAD when compared with control groups (118.2 + 22.7mg/dl versus 105 + 19.6 mg/dl, P
ISSN:0970-1915