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Relationship Between Body Iron Status and Cardiovascular Risk Factors in Patients with Coronary Artery Disease

Iron is an essential trace element. It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and...

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Published in:	Indian journal of clinical biochemistry 2014-12, Vol.29 (S1), p.S141
Main Authors:	Chopra, Sunny, Lal, A.K, Dhar, Meenakshi, Vij, C
Format:	Article
Language:	English
Subjects:	Atherosclerosis Cardiac patients Coronary heart disease Development and progression Enzymes Ferritin Medical research Medicine, Experimental Risk factors
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container_title	Indian journal of clinical biochemistry
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creator	Chopra, Sunny Lal, A.K Dhar, Meenakshi Vij, C
description	Iron is an essential trace element. It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and total iron binding capacity (TIBC) in the causation of coronary artery disease (CAD). The study group consisted of 40 angiographically confirmed cases of CAD and 40 normal healthy controls taken from HIMS, Dehradun. The blood samples were taken after 10-12 hours of fasting. Serum lipids, serum lipoproteins, serum iron and TIBC were estimated by autoanalyzer (Dxc 900 Beckman Coulter). Serum ferritin was measured on Mini VIDAS and MDA was being done by Thiobarbituric acid method. The ratio of Total cholesterol and HDL was significantly raised in CAD patients (5.07) than controls (3.48). The levels of MDA were high in patients (19.9 + 1.7 pmol/l) as compared to controls (4.9 + 1.0 pmol/l). Serum iron and Serum ferritin levels were significantly high in patients with CAD when compared with control groups (118.2 + 22.7mg/dl versus 105 + 19.6 mg/dl, P
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It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and total iron binding capacity (TIBC) in the causation of coronary artery disease (CAD). The study group consisted of 40 angiographically confirmed cases of CAD and 40 normal healthy controls taken from HIMS, Dehradun. The blood samples were taken after 10-12 hours of fasting. Serum lipids, serum lipoproteins, serum iron and TIBC were estimated by autoanalyzer (Dxc 900 Beckman Coulter). Serum ferritin was measured on Mini VIDAS and MDA was being done by Thiobarbituric acid method. The ratio of Total cholesterol and HDL was significantly raised in CAD patients (5.07) than controls (3.48). The levels of MDA were high in patients (19.9 + 1.7 pmol/l) as compared to controls (4.9 + 1.0 pmol/l). Serum iron and Serum ferritin levels were significantly high in patients with CAD when compared with control groups (118.2 + 22.7mg/dl versus 105 + 19.6 mg/dl, P<0.001) and (218.3 + 58.6mg/dl versus 139.8 + 66 mg/dl, P<0.0001) respectively. TIBC levels were lower in patients than controls (309.8 + 79.2 versus 231.5 + 61.2, P<0.0001). This study concluded that increased levels of serum iron, ferritn and MDA might consider as risk factor for CAD in conjunction with other risk factors. The caution should be exercised in administration of iron supplements to patients of CAD.</description><identifier>ISSN: 0970-1915</identifier><language>eng</language><publisher>Springer</publisher><subject>Atherosclerosis ; Cardiac patients ; Coronary heart disease ; Development and progression ; Enzymes ; Ferritin ; Medical research ; Medicine, Experimental ; Risk factors</subject><ispartof>Indian journal of clinical biochemistry, 2014-12, Vol.29 (S1), p.S141</ispartof><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Chopra, Sunny</creatorcontrib><creatorcontrib>Lal, A.K</creatorcontrib><creatorcontrib>Dhar, Meenakshi</creatorcontrib><creatorcontrib>Vij, C</creatorcontrib><title>Relationship Between Body Iron Status and Cardiovascular Risk Factors in Patients with Coronary Artery Disease</title><title>Indian journal of clinical biochemistry</title><description>Iron is an essential trace element. It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and total iron binding capacity (TIBC) in the causation of coronary artery disease (CAD). The study group consisted of 40 angiographically confirmed cases of CAD and 40 normal healthy controls taken from HIMS, Dehradun. The blood samples were taken after 10-12 hours of fasting. Serum lipids, serum lipoproteins, serum iron and TIBC were estimated by autoanalyzer (Dxc 900 Beckman Coulter). Serum ferritin was measured on Mini VIDAS and MDA was being done by Thiobarbituric acid method. The ratio of Total cholesterol and HDL was significantly raised in CAD patients (5.07) than controls (3.48). The levels of MDA were high in patients (19.9 + 1.7 pmol/l) as compared to controls (4.9 + 1.0 pmol/l). Serum iron and Serum ferritin levels were significantly high in patients with CAD when compared with control groups (118.2 + 22.7mg/dl versus 105 + 19.6 mg/dl, P<0.001) and (218.3 + 58.6mg/dl versus 139.8 + 66 mg/dl, P<0.0001) respectively. TIBC levels were lower in patients than controls (309.8 + 79.2 versus 231.5 + 61.2, P<0.0001). This study concluded that increased levels of serum iron, ferritn and MDA might consider as risk factor for CAD in conjunction with other risk factors. 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It has a pivotal role in maintaining various cellular functions and enzyme reactions; whereas, iron overload has been known as a risk factor in progression of atherosclerosis. The aim of this study was to investigate the role of the serum iron, serum ferritin and total iron binding capacity (TIBC) in the causation of coronary artery disease (CAD). The study group consisted of 40 angiographically confirmed cases of CAD and 40 normal healthy controls taken from HIMS, Dehradun. The blood samples were taken after 10-12 hours of fasting. Serum lipids, serum lipoproteins, serum iron and TIBC were estimated by autoanalyzer (Dxc 900 Beckman Coulter). Serum ferritin was measured on Mini VIDAS and MDA was being done by Thiobarbituric acid method. The ratio of Total cholesterol and HDL was significantly raised in CAD patients (5.07) than controls (3.48). The levels of MDA were high in patients (19.9 + 1.7 pmol/l) as compared to controls (4.9 + 1.0 pmol/l). Serum iron and Serum ferritin levels were significantly high in patients with CAD when compared with control groups (118.2 + 22.7mg/dl versus 105 + 19.6 mg/dl, P<0.001) and (218.3 + 58.6mg/dl versus 139.8 + 66 mg/dl, P<0.0001) respectively. TIBC levels were lower in patients than controls (309.8 + 79.2 versus 231.5 + 61.2, P<0.0001). This study concluded that increased levels of serum iron, ferritn and MDA might consider as risk factor for CAD in conjunction with other risk factors. The caution should be exercised in administration of iron supplements to patients of CAD.</abstract><pub>Springer</pub></addata></record>
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subjects	Atherosclerosis Cardiac patients Coronary heart disease Development and progression Enzymes Ferritin Medical research Medicine, Experimental Risk factors
title	Relationship Between Body Iron Status and Cardiovascular Risk Factors in Patients with Coronary Artery Disease
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