Leptin and Adiponectin as Predictors of Metabolic Syndrome in Psoriasis: A Case-Control Study

Psoriasis is a chronic, immune mediated inflammatory skin disease. It has been considered of late as a disorder with systemic inflammation that could contribute to various systemic events like Metabolic Syndrome (MetS). Adiponectin and leptin are cytokines that are mainly secreted from the adipose t...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.30 (S1), p.S31
Main Authors: Shenoy, Chetana, Shenoy, M. Manjunath, Shantaram, Manjula
Format: Article
Language:English
Subjects:
Adipose tissues
Analysis
Insulin resistance
Leptin
Psoriasis
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Summary:Psoriasis is a chronic, immune mediated inflammatory skin disease. It has been considered of late as a disorder with systemic inflammation that could contribute to various systemic events like Metabolic Syndrome (MetS). Adiponectin and leptin are cytokines that are mainly secreted from the adipose tissue. They are believed to be a link between obesity, insulin resistance and endothelial dysfunction. This study was undertaken to analyze the role of adiponectin and leptin in relation to MetS in psoriasis. We performed a case-control study on 60 psoriasis patients and 60 subjects without psoriasis (Control). Cases and controls were divided into four groups based on the presence and absence of MetS. Serum adiponectin and leptin levels were measured in all four groups. The overall serum adiponectin levels were significantly reduced and serum leptin levels were significantly increased in psoriasis patients when compared with controls (p value < 0.05). Serum leptin levels were found to be significantly different in the four groups (p value = 0.05). The highest mean value of serum leptin (32.05 ng/ml) was observed in psoriasis with MetS group and lowest mean value of leptin (18.74 ng/ml) in controls without MetS (p value = 0.011). The lowest mean value of serum adiponectin (8108.33 ng/ml) was observed in psoriasis with MetS group and highest mean value of adiponectin (10623.92 ng/ml) in controls without MetS. Hyperleptinemia and hypoadiponectinemia is associated with psoriasis. They may play a role in the pathogenesis of psoriasis and may also contribute to MetS in psoriasis.
ISSN:0970-1915