Lipid Profile and Glycosylated Hemoglobin Status of Gestational Diabetic Patients and Healthy Pregnant Women

Alteration in insulin sensitivity in Gestational diabetes mellitus (GDM) not only affects glucose homeostasis but also affects lipid metabolism as well. Glycosylated hemoglobin ([HbA.sub.1c]) gives us an idea of blood glucose control prior to the actual estimation of blood glucose. The objective of...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.30 (S1), p.S46
Main Authors: Goel, Richa, Chugh, Kiran, Ghalaut, Veena Singh, Kumar, Himanshu Devender
Format: Article
Language:English
Subjects:
Blood sugar
Care and treatment
Diabetes
Diabetics
Glucose tolerance tests
Glycosylated hemoglobin
Health aspects
Physiological aspects
Pregnancy
Pregnant women
Women
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Summary:Alteration in insulin sensitivity in Gestational diabetes mellitus (GDM) not only affects glucose homeostasis but also affects lipid metabolism as well. Glycosylated hemoglobin ([HbA.sub.1c]) gives us an idea of blood glucose control prior to the actual estimation of blood glucose. The objective of the study was to determine serum lipid profile, blood glucose levels in oral glucose tolerance test (OGTT) and [HbA.sub.1c] in GDM patients and healthy pregnant women. Thirty healthy pregnant women (controls) and thirty age and gestation matched women with singleton pregnancy; newly diagnosed with GDM satisfying the inclusion and exclusion criteria were included in the study. The serum was analysed for lipid profile, blood glucose and [HbA.sub.1c]. The results showed that fasting blood glucose level, blood glucose level after 1 hour and 2 hours after 75 gm oral glucose administration (OGTT) were significantly higher in patients than in controls (p < 0.001). [HbA.sub.1c] was significantly higher in GDM patients as compared to controls (p < 0.001). There was a significant increase in serum cholesterol, serum triglyceride and serum VLDL level in cases when compared to healthy pregnant women (p < 0.05). Our study suggests that timely estimation of blood glucose, lipid profile and [HbA.sub.1c] is very essential to improve adverse pregnancy outcomes in GDM as well as we can avoid further deterioration of the disease process by early detection and prompt treatment.
ISSN:0970-1915