Coenzyme Q10 and its Emerging Role as an Antineoplastic Agent

Coenzyme Q10 (CoQ10) is a naturally occurring, lipid soluble substance. It is a key molecule in all energy requiring processes including proliferation, apoptosis, angiogenesis and immune function, suggesting the potential for multiple roles in the initiation and progression of cancer. It is also kno...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.30 (S1), p.S87
Main Authors: Verma, Monica, Soni, Abhishek, Ghalaut, Veena Singh, Kaushal, Vivek
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Cancer
Electron transport
Enzymes
Prevention
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coenzyme Q10 (CoQ10) is a naturally occurring, lipid soluble substance. It is a key molecule in all energy requiring processes including proliferation, apoptosis, angiogenesis and immune function, suggesting the potential for multiple roles in the initiation and progression of cancer. It is also known as ubiquinone. It is an antioxidant and a redox coenzyme of the electron transport chain. This literature review was performed by conducting a systematic search of PUBMED, MEDLINE and PMC, including all articles up to November 2014. All articles were reviewed and were included if they were relevant to the topic, and deemed to be of good quality. The references for each article were reviewed to identify further articles of relevance. CoQ10 levels are altered in a number of oncological as well as non-oncological diseases. CoQ10 has an impact on the expression of many genes involved in metabolism, cellular transport, transcription control, and cell signalling, making CoQ10 a potent gene regulator. Supplementation of Co Q10 with chemotherapy to cancer patients reduces the tumour marker level thereby offering better cancer prognosis by reducing the risk of developing cancer recurrence and metastasis, improved quality of life. CoQ10 therapy has no serious side effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. CoQ10 has a role in carcinoma breast, cervix, lung, prostate, melanoma, cancer chemotherapy and cancer related fatigue. Future trends involving CoQ10 in many cancers needs more clinical trials for better understanding of CoQ10 efficacy.
ISSN:0970-1915