Association Between AST, ALT and CK In Cases of Dengue Infection: A Prospective Case Control Study

INTRODUCTION: Dengue is an endemic viral infection found in our country, known for its high morbidity and mortality. Existing biomarkers such as Alanine transaminase (ALT) and Aspartate transaminase (AST) have been associated with severe dengue but evidences are not conclusive. Recently, Creatine ki...

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Published in:Indian journal of clinical biochemistry 2022-05, Vol.32 (S1), p.S83
Main Authors: Gavel, Pratibha, Bharti, Sujit
Format: Article
Language:English
Subjects:
Creatine
Creatine kinase
Dengue
Development and progression
Enzyme-linked immunosorbent assay
Health aspects
Infection
Medical research
Medicine, Experimental
Mortality
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Summary:INTRODUCTION: Dengue is an endemic viral infection found in our country, known for its high morbidity and mortality. Existing biomarkers such as Alanine transaminase (ALT) and Aspartate transaminase (AST) have been associated with severe dengue but evidences are not conclusive. Recently, Creatine kinase (CK) has emerged as a biomarker of dengue infection. These biomarkers depict the underlying pathophysiological processes in dengue. AIM AND OBJECTIVE: We aimed to assess AST, ALT and CK in dengue infection and to assess the relationship amongst these biomarkers in dengue infection. MATERIALAND METHODS: This was a prospective cohort study of confirmed dengue patients and healthy controls. Blood samples from patients coming to the hospital were screened for NS 1 antigen by lateral flow chromatography. The blood samples which were found positive for NS 1 antigen were confirmed for the presence of IgM antibody by ELISA. The IgM positive samples and controls were then tested for AST, ALT and CK. RESULTS: The biomarkers of muscle and liver involvement were found to be elevated. There was positive association between AST, ALT and CK. CONCLUSION: The study concludes that CK is a good biomarker to assess the disease progression and severity. However, it is advised to use AST, ALT and CK in combination to assess the disease condition better. KEY WORDS: Dengue, Creatine Kinase, Alanine Transaminase, Aspartate Transminase
ISSN:0970-1915