Hepatoprotective activity of ethanolic extract of tuber of Actinoscirpus grossus Goetgh. D.A. Simpson against paracetamol induced hepatotoxicity in Wistar albino rats

INTRODUCTION-Actinoscirpus grossus (L.f.) Goetgh. & D.A. Simpson commonly known as Kasheruk in Indian system of Medicine, belongs to Cyperaceae family. A. grossus has been indicated for different ailments such as anti diarrheal, anti emetic. The root is slightly sweet in taste and indicated for...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.32 (S1), p.S120
Main Authors: Ganapathi, Savin Chanthala, Holla, Rajendra, Shankara, Shivaraja
Format: Article
Language:English
Subjects:
Acetaminophen
Diarrhea
Gastrointestinal agents
Liver
Liver diseases
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Summary:INTRODUCTION-Actinoscirpus grossus (L.f.) Goetgh. & D.A. Simpson commonly known as Kasheruk in Indian system of Medicine, belongs to Cyperaceae family. A. grossus has been indicated for different ailments such as anti diarrheal, anti emetic. The root is slightly sweet in taste and indicated for cooling, laxative and liver disorders. AIMS & OBJECTIVES: Aim of this study is to evaluate the hepatoprotective activity of Actinoscirpus grossus (L.f.) Goetgh & D.A Simpson against paracetamol induced hepatotoxicity in Wistar albino rats. MATERIALS AND METHODS: Hepatotoxicity was induced by giving high dose of paracetamol 3g/kg bodyweight followed by A. grossus (200mg/kg,400mg/ kg), and reference standard drugs (Silymarin 50mg/kg, liv52 5ml/kg). Test and reference standard drugs were administered orally for 15 consecutive days. On 15th day blood was collected in the tubes and biochemical investigation was done. All the animals were sacrificed. Liver is dissected out, cleaned to remove extraneous tissues, volume and weight of liver is noted and piece of liver tissue was preserved in 10% formalin for histopathological processing RESULTS & CONCLUSION: High dose of paracetamol 3g/kg manifested by statistically significant increase in liver marker enzymes such as serum SGOT. SGPT, Alkaline phosphatase, and bilirubin level. After administration of A. grossus 200mg/kg and 400mg/kg and reference standard drugs lowered activities of liver enzyme activities. Results obtained from histopathological studies supported the hepatoprotective activity of A. grossus against paracetamol induced hepatotoxicity. Analysis of the data generated during the study indicates paracetamol produced significant liver injury at the dose injected. Injurious effects were reversed by both reference standard and test drug. KEY WORDS: Hepatotoxicity, A. grossus, hepatoprotective activity
ISSN:0970-1915