A Study of Mineral Metabolism Parameters in Different Stages of Chronic Kidney Disease

INTRODUCTION: Chronic kidney disease (CKD) is a highly prevalent condition having high morbidity and mortality rates. Mineral metabolism disturbances are commonly associated with CKD and this may in turn lead to cardiovascular diseases and bone disorders. The aim of the present study is to assess th...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.33 (S1), p.S44
Main Authors: Chendar, B, Khan, Siraj Ahmed, Mohan, Iyyapu Krishna, Sreedevi, N.N, Bhaskar, M. Vijaya, Baba, K.S.S. Sai
Format: Article
Language:English
Subjects:
Analysis
Cardiovascular diseases
Chronic kidney failure
Health aspects
Mortality
Physiological aspects
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Summary:INTRODUCTION: Chronic kidney disease (CKD) is a highly prevalent condition having high morbidity and mortality rates. Mineral metabolism disturbances are commonly associated with CKD and this may in turn lead to cardiovascular diseases and bone disorders. The aim of the present study is to assess the disturbances in mineral metabolism in different stages of CKD. MATERIAL AND METHOD: A total of 95 cases of CKD are recruited in the present study. A detailed history was taken and fasting sample was collected and analysed for serum Creatinine, Calcium, Phosphorus, Magnesium and electrolytes. These cases are divided into different stages of CKD depending on eGFR. The data was analysed by using Medcalc software. Non parametric variables are expressed as Median (interquartile range). These cases are compared with age matched healthy controls using Mann-whitney test, in between group analysis was done by kruskal-wallis test. A p < 0.05 is considered as significant. RESULTS: The median Calcium (mg/dl) concentration in cases is 8.5 (8-9.5) and is significantly lower compared to controls 9.6 (9.3-9.8). There is no statistically significant difference in calcium in different stages of CKD. The median phosphorus (mg/dl) concentration in cases is 3.8 (2.9-5.2) and is significantly higher as compared to controls 3.3(3.1-3.7). There is significantly higher concentration of phosphorus in stage V compared to other stages. There is no statistically significant difference in magnesium between cases and controls. Concentration of magnesium is significantly higher in stage V compared to other stages. Serum sodium and chloride is significantly low in cases as compared to controls and there is no significant difference in potassium concentration between cases and controls. CONCLUSION: This study shows how early some of the mineral metabolism parameter like phosphorus and magnesium varies with different stage and progressively changes until stage V. Many studies have shown that this mineral abnormalities may lead to secondary hyperparathyroidism, cardiovasular diseases and bone abnormalities in CKD patients, therefore CKD patients should be regularly screened for mineral metabolism parameters. KEYWORDS: Chronic kidney disease, Calcium, Phosphorus, Magnesium
ISSN:0970-1915