Liver Enzymes in Alcohol Dependence Syndrome Patients

Alcohol dependence syndrome (ADS) has become a global public health challenge because of its high prevalence and the concomitant increase in risk of liver disease, cardiovascular disease and premature death. Influence of alcohol use on liver metabolism is well recognized. This study was aimed at exa...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.34 (S1), p.S219
Main Authors: Raut, M, Ghimire, S, Yadav, B.K, Sharma, V.K, Bhattarai, A, Tuladhar, E.T
Format: Article
Language:English
Subjects:
Alcoholic beverages
Alcoholism
Drinking of alcoholic beverages
Liver
Liver cirrhosis
Medical research
Medicine, Experimental
Physiological aspects
Proteins
Psychiatrists
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Summary:Alcohol dependence syndrome (ADS) has become a global public health challenge because of its high prevalence and the concomitant increase in risk of liver disease, cardiovascular disease and premature death. Influence of alcohol use on liver metabolism is well recognized. This study was aimed at examining the association of liver markers like bilirubin, serum albumin, ??glutamyltransferase (GGT) and aminotransferase, with alcohol dependence syndrome patients. This cross-sectional study was conducted in TU Teaching Hospital. ADS patients were screened by the consultant psychiatrist using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire. A total of 89 patients scored positive on the AUDIT as having alcohol-related problems and were included in the study. Blood Pressure and other anthropometric parameters were measured while blood samples were analyzed for liver markers and other blood parameters. Mean age of cases and controls was 35.42 [+ or -] 5.6 & 34.53 [+ or -] 3.5 years respectively. The mean values of Gamma GT (181.02 [+ or -] 78.16), Alkaline Phosphatase (219.93 [+ or -] 76.87), albumin (36.61 [+ or -] 5.5). The mean values for serum bilirubin (total as well as direct), SGOT and SGPT were elevated significantly in cases as compared to the controls (p
ISSN:0970-1915