The Study of Association of Serum Malondialdehyde, Ceruloplasmin and Lipid Profile in Pre-Eclampsia: A Cross-Sectional Study

Introduction : Pre-eclampsia (PE) is a very common disease of pregnancy complicating about 5-10% of all pregnancies across the world. Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.36 (S1), p.S96
Main Authors: Sakarde, Apurva, Ahirwar, Ashok Kumar, Kavathekar, Parveen, Hardas, Vaijayanti
Format: Article
Language:English
Subjects:
Medical research
Medicine, Experimental
Preeclampsia
Risk factors
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Summary:Introduction : Pre-eclampsia (PE) is a very common disease of pregnancy complicating about 5-10% of all pregnancies across the world. Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of oxidative stress's markers such as serum malondialdehyde (MDA), ceruloplasmin and lipid profile in patients of preeclampsia. Materials and Methods: A cross-sectional study was conducted in which 100 pre -eclampsia patients and 50 healthy controls were included in the study. Pre--eclampsia patients were further subdivided into two groups, one group consisted of 50 mild preeclampsia patients and another group consisted of 50 severe pre eclampsia patients. Serum MDA, ceruloplasmin and lipid profile were estimated by spectrophotometry method. Results: Serum MDA and ceruloplasmin were significantly higher in preeclampsia patients as compared to healthy controls (p
ISSN:0970-1915