The Study of Association of Serum Malondialdehyde, Ceruloplasmin and Lipid Profile in Pre-Eclampsia: A Cross-Sectional Study

Introduction : Pre-eclampsia (PE) is a very common disease of pregnancy complicating about 5-10% of all pregnancies across the world. Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of...

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Published in:Indian journal of clinical biochemistry 2022-05, Vol.36 (S1), p.S96
Main Authors: Sakarde, Apurva, Ahirwar, Ashok Kumar, Kavathekar, Parveen, Hardas, Vaijayanti
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Language:English
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Medical research
Medicine, Experimental
Preeclampsia
Risk factors
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Ahirwar, Ashok Kumar
Kavathekar, Parveen
Hardas, Vaijayanti
description Introduction : Pre-eclampsia (PE) is a very common disease of pregnancy complicating about 5-10% of all pregnancies across the world. Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of oxidative stress's markers such as serum malondialdehyde (MDA), ceruloplasmin and lipid profile in patients of preeclampsia. Materials and Methods: A cross-sectional study was conducted in which 100 pre -eclampsia patients and 50 healthy controls were included in the study. Pre--eclampsia patients were further subdivided into two groups, one group consisted of 50 mild preeclampsia patients and another group consisted of 50 severe pre eclampsia patients. Serum MDA, ceruloplasmin and lipid profile were estimated by spectrophotometry method. Results: Serum MDA and ceruloplasmin were significantly higher in preeclampsia patients as compared to healthy controls (p
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Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of oxidative stress's markers such as serum malondialdehyde (MDA), ceruloplasmin and lipid profile in patients of preeclampsia. Materials and Methods: A cross-sectional study was conducted in which 100 pre -eclampsia patients and 50 healthy controls were included in the study. Pre--eclampsia patients were further subdivided into two groups, one group consisted of 50 mild preeclampsia patients and another group consisted of 50 severe pre eclampsia patients. Serum MDA, ceruloplasmin and lipid profile were estimated by spectrophotometry method. Results: Serum MDA and ceruloplasmin were significantly higher in preeclampsia patients as compared to healthy controls (p&lt;0.001). An altered lipid profile was seen in the patients of pre-eclampsia as compared to controls. Serum MDA showed a positive correlation with serum ceruloplasmin among the study population. On binary logistic analysis, serum MDA and ceruloplasmin showed a significant odd ratio to predict pre-eclampsia. Conclusion: Pre-eclampsia is associated with altered lipid profile and increased oxidative stress markers i.e serum MDA and ceruloplasmin in pre-eclampsia. Thus, serum MDA and ceruloplasmin may be considered as risk factors for pre-eclampsia. Key Points: Preeclampsia, Serum malondialdehyde (MDA), Ceruloplasmin, Lipid profile. 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Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of oxidative stress's markers such as serum malondialdehyde (MDA), ceruloplasmin and lipid profile in patients of preeclampsia. Materials and Methods: A cross-sectional study was conducted in which 100 pre -eclampsia patients and 50 healthy controls were included in the study. Pre--eclampsia patients were further subdivided into two groups, one group consisted of 50 mild preeclampsia patients and another group consisted of 50 severe pre eclampsia patients. Serum MDA, ceruloplasmin and lipid profile were estimated by spectrophotometry method. Results: Serum MDA and ceruloplasmin were significantly higher in preeclampsia patients as compared to healthy controls (p&lt;0.001). An altered lipid profile was seen in the patients of pre-eclampsia as compared to controls. Serum MDA showed a positive correlation with serum ceruloplasmin among the study population. On binary logistic analysis, serum MDA and ceruloplasmin showed a significant odd ratio to predict pre-eclampsia. Conclusion: Pre-eclampsia is associated with altered lipid profile and increased oxidative stress markers i.e serum MDA and ceruloplasmin in pre-eclampsia. Thus, serum MDA and ceruloplasmin may be considered as risk factors for pre-eclampsia. Key Points: Preeclampsia, Serum malondialdehyde (MDA), Ceruloplasmin, Lipid profile. 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Oxidative stress and its metabolites in the pathogenesis of PE has been considered as debated area. Hence, the aim of the present work is to study the association of oxidative stress's markers such as serum malondialdehyde (MDA), ceruloplasmin and lipid profile in patients of preeclampsia. Materials and Methods: A cross-sectional study was conducted in which 100 pre -eclampsia patients and 50 healthy controls were included in the study. Pre--eclampsia patients were further subdivided into two groups, one group consisted of 50 mild preeclampsia patients and another group consisted of 50 severe pre eclampsia patients. Serum MDA, ceruloplasmin and lipid profile were estimated by spectrophotometry method. Results: Serum MDA and ceruloplasmin were significantly higher in preeclampsia patients as compared to healthy controls (p&lt;0.001). An altered lipid profile was seen in the patients of pre-eclampsia as compared to controls. 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subjects Medical research
Medicine, Experimental
Preeclampsia
Risk factors
title The Study of Association of Serum Malondialdehyde, Ceruloplasmin and Lipid Profile in Pre-Eclampsia: A Cross-Sectional Study
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