Changes in Liver Function Parameters in Patients with COVID-19 admitted in Tertiary Care Hospital: RIMS Hospital

Background : COVID-19 outbreak caused by SARS-COV-2 which primarily targets lungs causing other organs dysfunction including liver have been reported. However studies on liver function in COVID 19 patients are limited. Hence, this study aimed to evaluate the Liver enzymes in COVID-19 cases admitted...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.36 (S1), p.S120
Main Author: Naorem, Sangeeta
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Enzymes
Health aspects
Liver
Liver diseases
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Summary:Background : COVID-19 outbreak caused by SARS-COV-2 which primarily targets lungs causing other organs dysfunction including liver have been reported. However studies on liver function in COVID 19 patients are limited. Hence, this study aimed to evaluate the Liver enzymes in COVID-19 cases admitted in RIMS, Imphal. Methodology: We performed a cross sectional study on the liver function parameters of 488 COVID-19 positive patients admitted in RIMS, Imphal during April 2020 to September 2020. The COVID-19 positivity was determined on basis of RNA real time PCR. Serum samples were analyzed using Randox Auto analyzer. Results: Out of 488 patients with COVID-19, 431cases (88.32%) had abnormal LFTs and 57 cases (11.68%) had normal LFTs. Out of these 431 cases 330 (76.57%) were males and 101 (23.43%) were females. Median age of abnormal LFTs cases was 35 years. The primary liver enzymes; AST, ALT, ALKP and GGT were found to be elevated in 79.3%, 78.1%, 30.8% and 25.5% cases respectively. However, serum albumin levels were low in 24.1% cases. Conclusion: The prevalence of abnormal LFTs in COVID-19 patients is relatively high (88.31%). Abnormal liver enzymes may be a frequent finding in COVID-19 cases. These patients may be at a higher risk of progressing to severe diseases and therefore they should be observed and evaluated frequently for further treatment. Keywords: Albumin, ALT, AST, ALKP, GGT
ISSN:0970-1915