Initial and Day Four B-hCG Levels as Predictors of Outcome of Single Dose Methotrexate Therapy in Medical Management of Tubal Ectopic Gestation

Aim and Objectives : To study initial and day 4[beta]-hCG levels as predictors of outcome of single dose methotrexate therapy in medical management of ectopic pregnancy. Material and Methods: Thirty patients after confirmed diagnoses of tubal ectopic pregnancy were enrolled in the study. [beta]-hCG...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.36 (S1), p.S138
Main Authors: Yadav, Neeraj, Kumari, Anuradha, Biswas, Ratna, Malik, Ekta
Format: Article
Language:English
Subjects:
Dosage and administration
Methotrexate
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Summary:Aim and Objectives : To study initial and day 4[beta]-hCG levels as predictors of outcome of single dose methotrexate therapy in medical management of ectopic pregnancy. Material and Methods: Thirty patients after confirmed diagnoses of tubal ectopic pregnancy were enrolled in the study. [beta]-hCG estimated using a sequential two step immunoenzymatic (sandwich) assay. Results: Out of 30 women who received inj MTX on day 0, 19 (63.3%) women were treated successfully with single dose of methotrexate (group 1), 8(26.6% women required second dose of methotrexate and 3(10%) women required surgery. Women who required second dose or surgery were treatment failure (group2) (36.6%) with single dose methotrexate regimen. Mean initial [beta]-hCG [beta]-hCG level was 2294.92 [+ or -] 1162.93 mIU/mL in group 1 and 3831.18 [+ or -] 1066.83 mIU/mL in group 2. The difference of mean was statistically significant between group 1 and group 2 on day 0, day 4 and day 7. Conclusion: Results in present study favour therapeutic intervention with second dose of methotrexate on day 4 against day 7 as in the current protocol in women with rising trend of [beta]-hCG between day 0 and day 4. Keywords: [beta]-hCG, Predictors, Single Dose Methotrexate Therapy, Tubal Ectopic Gestation, Keywords : [beta]-hCG, Predictors, Single Dose Methotrexate Therapy, Tubal Ectopic Gestation,
ISSN:0970-1915