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Randomized clinical trial with fractional CO2 laser and Clobetasol in the treatment of Vulvar Lichen Sclerosus: a clinic study of feasibility

The main objective of the study was to describe and compare the feasibility of using fractional CO.sub.2 laser to the usual treatment with Clobetasol. Randomized clinical trials brought together 20 women from a Brazilian university hospital, 9 of them were submitted to Clobetasol treatment and 11 to...

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Bibliographic Details
Published in:BMC Research Notes 2023, Vol.16 (1)
Main Authors: Salgado, Hakayna Calegaro, Drumond, Denise Gasparetti, Pannain, Gabriel Duque, de Melo e Costa, Louise Gracielle, Sampaio, Fernanda Souza, Leite, Isabel Cristina Gonçalves
Format: Report
Language:English
Online Access:Get full text
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Summary:The main objective of the study was to describe and compare the feasibility of using fractional CO.sub.2 laser to the usual treatment with Clobetasol. Randomized clinical trials brought together 20 women from a Brazilian university hospital, 9 of them were submitted to Clobetasol treatment and 11 to laser therapy. Sociodemographic data were obtained and quality of life parameters, vulvar anatomy, self-perception and histopathological analysis of vulvar biopsies were evaluated. Evaluations were made before the beginning of the treatment, during its implementation, right after its completion (3 months), and 12 months after. The SPSS 14.0 software was used, obtaining descriptive measurements. The level of significance adopted was 5%. The clinical/anatomical characteristics of the vulva did not differ between the treatment groups, as much before as after its performance. There was no statistically significant difference between the treatments performed regarding the impact on the life quality of the patients. A higher satisfaction degree with the treatment was obtained with the patients in the Laser group in the third month of evaluation. Laser therapy also revealed higher occurrence of telangiectasia after treatment completion. Fractional CO2 laser has proven to be well accepted and is a promising therapeutic option.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-023-06300-7