Lipid accumulation product : a systematic review and meta-analysis

Background Lipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analy...

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Published in:Lipids in health and disease 2023-03, Vol.22 (1)
Main Authors: Ebrahimi, Menooa, Seyedi, Seyed Arsalan, Nabipoorashrafi, Seyed Ali, Rabizadeh, Soghra, Sarzaeim, Mojdeh, Yadegar, Amirhossein, Mohammadi, Fatemeh, Bahri, Razman Arabzadeh, Pakravan, Peyman, Shafiekhani, Paria, Nakhjavani, Manouchehr, Esteghamati, Alireza
Format: Article
Language:English
Subjects:
Body size
Diagnosis
Fatty liver
Health aspects
Measurement
Physiological aspects
Triglycerides
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Summary:Background Lipid accumulation product (LAP) is an index calculated by waist circumference (WC) and triglyceride (TG), which reflects lipid toxicity. This study aims to investigate the association between the LAP index and nonalcoholic fatty liver disease (NAFLD) in a systematic review and meta-analysis. Methods and results PubMed, Scopus, and Web of Science online databases were searched for eligible studies that investigated the association of the LAP index and NAFLD. Sixteen observational studies with 96,101 participants, including four cohort studies, one case-control study and 11 cross-sectional studies with baseline data, were entered into this analysis. Fourteen studies reported a significant association between the LAP index and NAFLD, and two reported that this relation was not significant; two different meta-analyses (1- mean difference (MD) and 2- bivariate diagnostic test accuracy [DTA]) were conducted using Stata version 14. The LAP index was compared in subjects with and without NAFLD, and the difference was significant with 34.90 units (CI 95: 30.59-39.31, P < 0.001) of the LAP index. The DTA meta-analysis was conducted and showed that the LAP index pooled sensitivity and specificity for screening of NAFLD were 94% (CI95: 72%-99%, I.sup.2 = 99%, P < 0.001) and 85% (CI95: 62%-96%, I.sup.2 = 99%, P < 0.001), respectively. Conclusion The LAP Index is an inexpensive, sensitive, and specific method to evaluate NAFLD and may be valuable for NAFLD screening. Keywords: Insulin resistance, Lipid accumulation product (LAP), Liver disease (NAFLD), Meta-analysis, Nonalcoholic fatty liver disease
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-023-01802-6