Prevalence of Antimicrobial Resistance and Clonal Relationship in ESBL/AmpC-Producing IProteus mirabilis/I Isolated from Meat Products and Community-Acquired Urinary Tract Infection in Southern Brazil

The present study aimed to evaluate the prevalence of antimicrobial resistance and clonal relationships in Proteus mirabilis isolated from chicken meat, beef, pork, and community-acquired urinary tract infections (UTI-CA). Chicken meat isolates showed the highest multidrug resistance (MDR), followed...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-02, Vol.12 (2)
Main Authors: Sanches, Matheus Silva, Silva, Luana Carvalho, Silva, Caroline Rodrigues da, Montini, Victor Hugo, Oliva, Bruno Henrique Dias de, Guidone, Gustavo Henrique Migliorini, Nogueira, Mara Corrêa Lelles, Menck-Costa, Maísa Fabiana, Kobayashi, Renata Katsuko Takayama, Vespero, Eliana Carolina, Rocha, Sergio Paulo Dejato
Format: Article
Language:English
Subjects:
Beta lactamases
Drug resistance in microorganisms
Health aspects
Urinary tract infections
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Summary:The present study aimed to evaluate the prevalence of antimicrobial resistance and clonal relationships in Proteus mirabilis isolated from chicken meat, beef, pork, and community-acquired urinary tract infections (UTI-CA). Chicken meat isolates showed the highest multidrug resistance (MDR), followed by those from pork and UTI-CA, whereas beef had relatively few MDR strains. All sources had strains that carried bla[sub.CTX-M-65], whereas bla[sub.CTX-M-2] and bla[sub.CMY-2] were only detected in chicken meat and UTI-CA isolates. This indicates that chicken meat should be considered an important risk factor for the spread of P. mirabilis carrying ESBL and AmpC. Furthermore, ESBL/AmpC producing strains were resistant to a greater number of antimicrobials and possessed more resistance genes than non-producing strains. In addition, the antimicrobial resistance genes qnrD, aac(6′)-Ib-cr, sul1, sul2, fosA3, cmlA, and floR were also found. Molecular typing showed a genetic similarity between chicken meat and UTI-CA isolates, including some strains with 100% similarity, indicating that chicken can be a source of P. mirabilis causing UTI-CA. It was concluded that meat, especially chicken meat, can be an important source of dissemination of multidrug-resistant P. mirabilis in the community.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12020370