IPseudomonas aeruginosa/I and the Complement System: A Review of the Evasion Strategies

The increasing emergence of multidrug resistant isolates of P. aeruginosa causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the first hours and without time to select the most ap...

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Bibliographic Details
Published in:Microorganisms (Basel) 2023-03, Vol.11 (3)
Main Authors: González-Alsina, Alex, Mateu-Borrás, Margalida, Doménech-Sánchez, Antonio, Albertí, Sebastián
Format: Article
Language:English
Subjects:
Bacteremia
Causes of
Complement system
Complications and side effects
Development and progression
Health aspects
Immune response
Physiological aspects
Pseudomonas aeruginosa
Pseudomonas aeruginosa infections
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Summary:The increasing emergence of multidrug resistant isolates of P. aeruginosa causes major problems in hospitals worldwide. This concern is particularly significant in bloodstream infections that progress rapidly, with a high number of deaths within the first hours and without time to select the most appropriate treatment. In fact, despite improvements in antimicrobial therapy and hospital care, P. aeruginosa bacteremia remains fatal in about 30% of cases. The complement system is a main defensive mechanism in blood against this pathogen. This system can mark bacteria for phagocytosis or directly lyse it via the insertion of a membrane attack complex in the bacterial membrane. P. aeruginosa exploits different strategies to resist complement attack. In this review for the special issue on “bacterial pathogens associated with bacteriemia”, we present an overview of the interactions between P. aeruginosa and the complement components and strategies used by this pathogen to prevent recognition and killing by the complement system. A thorough understanding of these interactions will be critical in order to develop drugs to counteract bacterial evasion mechanisms.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms11030664