Effects of Ethanolic and Aqueous Extracts of IGarcinia gardneriana/I Leaves in an In Vivo Experimental Model Induced by a Hyperlipidic Diet

• Published in: Nutrients 2023-03, Vol.15 (6)
• Main Authors: Santo, Bruna Larissa Spontoni do Espirito, Santana, Lidiani Figueiredo, Kato Junior, Wilson Hino, Araújo, Felipe de Oliveira de, Tatara, Mariana Bento, Croda, Júlio, Bogo, Danielle, Freitas, Karine de Cássia, Guimarães, Rita de Cássia Avellaneda, Hiane, Priscila Aiko, Pott, Arnildo, Filiú, Wander Fernando de Oliveira, Faria, Bernardo Bacelar de, Figueiredo, Patrícia de Oliveira, do Nascimento, Valter Aragão, Ayres, Frederico Louveira, Bastos, Paulo Roberto Haidamus de Oliveira
• Format: Article
• Language: English
• Subjects: Blood lipids; Chemical properties; Health aspects; Materia medica, Vegetable; Obesity; Physiological aspects; Phytochemicals; Plant extracts; Prevention
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15061308

The study of medicinal plants, such as the genus Garcinia (Clusiaceae), in the treatment of non-communicable chronic diseases has aroused the interest of researchers. However, there are no studies in the literature that have investigated the effects of Garcinia gardneriana in experimental models of obesity for possible metabolic alterations. Swiss mice receiving a high-fat diet were supplemented with aqueous or ethanolic extract of G. gardneriana at doses of 200 or 400 mg/kg/day. It was found that there was a reduction in food consumption in experimental groups compared with the control groups, and the group supplemented with aqueous extract at a dose of 200 mg/kg/daydisplayed a reduction in weight. The results showed an increase in the values of high density lipoprotein (HDL-c), total cholesterol, triglycerides and fasting blood glucose. G. gardneriana did not protect against insulin resistance, and caused in an increase in monocyte chemoattractant protein-1 (MCP-1) concentrations and a reduction in interleukin 10 (IL-10). In addition, hepatic steatosis and microvesicular steatosis were indicated. It was revealed that, under the experimental conditions in the study, G. gardneriana did not prevent weight gain or comorbidities; that is, a different behavior was obtained from that described in the literature with regard to the medicinal potential of the Garcinia species, which is probably related to the phytochemical properties.