Protection against Oxidative Stress and Metabolic Alterations by Synthetic Peptides Derived from IErythrina edulis/I Seed Protein

• Published in: Antioxidants 2022-10, Vol.11 (11)
• Main Authors: Rodríguez-Arana, Nathaly, Jiménez-Aliaga, Karim, Intiquilla, Arturo, León, José A, Flores, Eduardo, Zavaleta, Amparo Iris, Izaguirre, Víctor, Solis-Calero, Christian, Hernández-Ledesma, Blanca
• Format: Article
• Language: English
• Subjects: Peptides; Physiological aspects
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox11112101

The ability of multifunctional food-derived peptides to act on different body targets make them promising alternatives in the prevention/management of chronic disorders. The potential of Erythrina edulis (pajuro) protein as a source of multifunctional peptides was proven. Fourteen selected synthetic peptides identified in an alcalase hydrolyzate from pajuro protein showed in vitro antioxidant, anti-hypertensive, anti-diabetic, and/or anti-obesity effects. The radical scavenging properties of the peptides could be responsible for the potent protective effects observed against the oxidative damage caused by FeSO[sub.4] in neuroblastoma cells. Moreover, their affinity towards the binding cavity of angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) were predicted by molecular modeling. The results demonstrated that some peptides such as YPSY exhibited promising binding at both enzymes, supporting the role of pajuro protein as a novel ingredient of functional foods or nutraceuticals for prevention/management of oxidative stress, hypertension, and metabolic-alteration-associated chronic diseases.