Untargeted Metabolomics Used to Describe the Chemical Composition, Antioxidant and Antimicrobial Effects of Extracts from IPleurotus/I spp. Mycelium Grown in Different Culture Media

Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 pathways. Comparisons were made between the metab...

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Published in:Antibiotics (Basel) 2022-10, Vol.11 (11)
Main Authors: Flores, Giancarlo Angeles, Girometta, Carolina Elena, Cusumano, Gaia, Angelini, Paola, Tirillini, Bruno, Ianni, Federica, Blasi, Francesca, Cossignani, Lina, Pellegrino, Roberto Maria, Emiliani, Carla, Venanzoni, Roberto, Venturella, Giuseppe, Colasuonno, Pasqualina, Cirlincione, Fortunato, Gargano, Maria Letizia, Zengin, Gokhan, Acquaviva, Alessandra, Di Simone, Simonetta Cristina, Orlando, Giustino, Menghini, Luigi, Ferrante, Claudio
Format: Article
Language:English
Subjects:
Antioxidants
Escherichia coli
Ethylenediaminetetraacetic acid
Instrument industry
Plant metabolites
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Summary:Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 pathways. Comparisons were made between the metabolic profiles of Pleurotus spp. mycelia grown in two substrates: Potato-dextrose-agar-PDA, used as control (S1), and PDA enriched with 0.5 % of wheat straw (S2). The main finding was that the metabolic pathways are strongly influenced by the chemical composition of the growth substrate. The antibacterial effects were particularly evident against Escherichia coli, whereas Arthroderma curreyi (CCF 5207) and Trichophyton rubrum (CCF 4933) were the dermatophytes more sensitive to the mushroom extracts. The present study supports more in-depth investigations, aimed at evaluating the influence of growth substrate on Pleurotus spp. antimicrobial and antioxidant properties.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11111468