Rational Use of Antibiotics and Education Improved IAeromonas/I Necrotizing Fasciitis Outcomes in Taiwan: A 19-Year Experience

Background. Aeromonas necrotizing fasciitis (NF) causes high rates of amputation and mortality, even after aggressive surgical debridement and antibacterial therapy. This study investigated the effects of rational use of antibiotics and education by infectious disease (ID) physicians on Aeromonas NF...

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Published in:Antibiotics (Basel) 2022-12, Vol.11 (12)
Main Authors: Huang, Tsung-Yu, Tsai, Yao-Hung, Lee, Ching-Yu, Hsu, Wei-Hsiu, Hsiao, Cheng-Ting, Huang, Yao-Kuang, Li, Yen-Yao, Chen, Jiun-Liang, Kuo, Shu-Fang, Hsiao, Jo-Chun, Li, Hsing-Jung, Hung, Chien-Hui, Peng, Kuo-Ti
Format: Article
Language:English
Subjects:
Antibacterial agents
Canada
Emergency medical services
Metronidazole
Mortality
Necrotizing fasciitis
Patient outcomes
Penicillin G
Taiwan
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Summary:Background. Aeromonas necrotizing fasciitis (NF) causes high rates of amputation and mortality, even after aggressive surgical debridement and antibacterial therapy. This study investigated the effects of rational use of antibiotics and education by infectious disease (ID) physicians on Aeromonas NF treatment outcomes. Methods. Retrospective review for conducted for four years (period I, without an ID physician, December 2001 to December 2005) and 15 years (period II, with an ID physician, January 2006 to March 2021). In period II, the hospital-wide computerized antimicrobial approval system (HCAAS) was also implemented. A pretest-posttest time series analysis compared the two periods. Differences in clinical outcomes, demographics, comorbidities, signs and symptoms, laboratory findings, Aeromonas antibiotic susceptibility, and antibiotic regimens were compared between the two periods. Results. There were 19 patients in period I and 53 patients in period II. Patients had a lower rate of amputation or mortality in period II (35.8%) compared with period I (63.2%). Forty-four patients (61.1%) had polymicrobial infections. In the emergency room, the rate of misdiagnosis decreased from 47.4% in period I to 28.3% in period II, while effective empiric antibiotic usage increased from 21.1% in period I to 66.0% in period II. After the ID physician's adjustment, 69.4% received monotherapy in period II compared to 33.3% in period I. Conclusions. Because Aeromonas NF had a high mortality rate and was often polymicrobial, choosing an antibiotic regimen was difficult. Using the HCAAS by an experienced ID physician can improve rational antibiotic usage and clinical outcomes in Aeromonas NF.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11121782